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Factor XII Concentrations and Risk of Intracerebral Haemorrhage. A Prospective Case-Referent Study
Journal of Stroke & Cerebrovascular Diseases ( IF 2.0 ) Pub Date : 2021-01-04 , DOI: 10.1016/j.jstrokecerebrovasdis.2020.105565
Kristina Johansson , Lars Johansson , Torbjörn K. Nilsson , Marcus M. Lind

Objectives

In a previous pilot study, we found an association between high factor XII levels and risk of haemorrhagic stroke suggesting that factor XII is a risk marker for intracerebral haemorrhage (ICH). The aim of this study was to further investigate the association between factor XII and risk of ICH in a larger population.

Materials and Methods

This study was conducted as a prospective nested case-referent study. All participants underwent a health examination and blood sampling for factor XII analysis at baseline. Cases were defined as participants who were diagnosed with a first-ever ICH between 1985 and 2000. Two referents were matched to each case.

Results

We identified 70 individuals with first-ever ICH and 137 matched referents who had undergone a health examination and donated blood samples before the ICH event. The mean age was 54 years, and 33% were women. The median time-to-event was 3.5 years (range 0.04 to 10.2 years). Conditional logistic regression showed no association between factor XII and risk of ICH, (odds ratio 1.06 per SD; [95% confidence interval: 0.57–1.97] in a multivariable model).

Conclusions

A previous finding of an association between high concentration of factor XII and risk of ICH could not be replicated in this larger study.



中文翻译:

XII因子浓度和脑出血风险。前瞻性案例研究

目标

在先前的先期研究中,我们发现XII因子水平高与出血性中风的风险之间存在关联,这表明XII因子是脑出血(ICH)的危险标志。这项研究的目的是进一步调查XII因子与较大人群中ICH风险之间的关联。

材料和方法

这项研究是作为前瞻性嵌套案例参考研究进行的。在基线时,所有参与者都进行了健康检查和血液采样以进行XII因子分析。病例定义为在1985年至2000年间首次被诊断患有ICH的参与者。每个病例都配备了两名对象。

结果

我们确定了70例有史以来首例ICH的患者和137名匹配对象,他们在ICH事件之前接受了健康检查并捐赠了血液样本。平均年龄为54岁,女性为33%。平均事件发生时间为3.5年(范围为0.04至10.2年)。条件logistic回归显示XII因子与ICH风险之间无关联(在多变量模型中,赔率比为1.06 / SD; [95%置信区间:0.57-1.97])。

结论

在这项较大的研究中,无法重复发现先前发现的高浓度的因子XII与ICH风险之间的关联。

更新日期:2021-01-05
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