Oral candidiasis is an infection that occurs inside of the cheek and oral cavity which is very painful. Treatment of oral candidiasis is very important for its commonness and the inadequate medication options are available for the treatment. Synthesis and evaluation of Poly (acrylamide) loaded thymol nanogelalternative for conventional creams was the main aim of this study. Polyacrylamide nanogel was synthesized from acrylamide monomer using N, N’-methylene bisacrylamide (cross-linker) and Irgacure (initiator) by UV induced cross-linking. Variation of reaction parameters such as cross-linker, initiator, light intensity, and exposure time has been used for the optimization. Nanogel characteristics were evaluated through the In vitro drug release, Ex vivo permeation study, FTIR Spectroscopy, FESEM, and antifungal activity. From the results, the drug release was found 75.47% to 99.62%, while viscosity was observed in therange of 76.68 to 34.44 cps. The contour plots shows that when cross-linker concentration varied from 0.12 w/v to 0.68 w/v, viscosity was increased from 34.44 cps to 76.68 cps with respect to UV curing time. The particle size distribution of nanogel was observed from 18.17 to 142.2 nm with average particle size of 132 nm and polydispersity index 0.4. Nanogel incorporated with thymol could be a new approach for topical delivery of thymol for antifungal activity compared to conventional cream.

口腔念珠菌病是发生在脸颊和口腔内部的一种非常痛苦的感染。口腔念珠菌病的治疗因其普遍性非常重要，并且可用的药物选择不充分。这项研究的主要目的是合成和评估聚丙烯酸酯负载的百里香酚纳米凝胶替代常规乳膏。通过N，N'-亚甲基双丙烯酰胺（交联剂）和Irgacure（引发剂），通过UV诱导交联，由丙烯酰胺单体合成聚丙烯酰胺纳米凝胶。反应参数的变化（例如交联剂，引发剂，光强度和曝光时间）已用于优化。通过体外药物释放，离体渗透研究，FTIR光谱，FESEM和抗真菌活性评估了纳米凝胶的特性。从结果来看 发现药物释放为75.47％至99.62％，而观察到的粘度为76.68至34.44cps。等高线图表明，当交联剂浓度从0.12 w / v变化到0.68 w / v时，相对于UV固化时间，粘度从34.44 cps增加到76.68 cps。观察到纳米凝胶的粒径分布为18.17至142.2nm，平均粒径为132nm，多分散指数为0.4。与传统乳膏相比，与百里酚结合的纳米凝胶可能是一种新的百里酚局部递送抗真菌活性的新方法。观察到纳米凝胶的粒径分布为18.17至142.2nm，平均粒径为132nm，多分散指数为0.4。与传统乳膏相比，与百里酚结合的纳米凝胶可能是一种新的百里酚局部递送抗真菌活性的新方法。观察到纳米凝胶的粒径分布为18.17至142.2nm，平均粒径为132nm，多分散指数为0.4。与传统乳膏相比，与百里酚结合的纳米凝胶可能是一种新的百里酚局部递送抗真菌活性的新方法。