Abstract

In the current research, a new Mn(II)-based coordination polymer, {(NH₂Me)₂[Mn₄(Hntb)₄(4,4′-bpy)(OH)₂] DMF} (1) have been formed by mixing the ligands of H₃ntb (4,4′,4′′-nitrilotris-benzoic) and 4,4′-bpy (4,4′-bipyridine). According to the results of UV detection, complex 1 has strong blue luminescence, which means that it can be used as a fluorescent probe for specific detection of Fe³⁺ ion in water with a K_sv value of 3.2 × 10⁴ M⁻¹. Furthermore, the treatment activity of the compound on sepsis treatment was assessed and the protentional mechanism was revealed. Firstly, the inflammatory cytokines released into the plasma was measured with ELISA detection kit. Then, the survival rate of the infected animals was recorded after compound treatment.

中文翻译：

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Mn（II）配位聚合物：通过减少炎性细胞因子的释放选择性检测Fe 3+离子和对败血症的治疗活性

摘要

在当前的研究中，一种新的基于Mn（II）的配位聚合物{（NH ₂ Me）₂ [Mn ₄（Hntb）₄（4,4'-bpy）（OH）₂ ] DMF}（1）已被开发出来。通过混合H ₃ ntb（4,4'，4''-硝苯并苯甲酸）和4,4'-bpy（4,4'-联吡啶）的配体形成。根据紫外线检测的结果，配合物1具有很强的蓝色发光，这意味着它可以用作荧光探针，用于K _sv值为3.2×10 ⁴  M ^-1的水中的Fe ³⁺离子的特异性检测。。此外，评估了该化合物对败血症治疗的治疗活性并揭示了其发病机理。首先，用ELISA检测试剂盒测定释放到血浆中的炎性细胞因子。然后，在复合处理后记录感染动物的存活率。