A new anthraquinone, 1,6-dihydroxy-2-hydroxymethyl-5-methoxy-9,10-anthracenedione (1), along with four known compounds, including 1,2-dimethoxyanthraquinone (2), morindone-5-methylether (3), scopoletin (4), and fraxidin (5) were isolated from the methylene chloride extract of the stem bark of Morinda lucida Benth. Structure elucidation was accomplished by analysis of the 1D and 2D NMR, IR and mass spectra. Compounds 1, 2, 4 and 5 were tested against five Salmonella strains. The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) were determined. The results indicated that the four compounds have different antibacterial activities, with MIC values ranging from 8 to 256 µg/mL. Among these four compounds, the best activity was observed for compound 4 against Salmonella enterica subsp. enterica serovar Typhimurim (STM), with a MIC value of 8 µg/mL. Compound 1 showed selective antibacterial activity toward the five Salmonella strains, with MICs of 16 µg/mL against STM, 32 µg/mL against S. enteritidis (STE), 64 µg/mL against S. enterica subsp. enterica serovar Typhi (ST) and S. enterica subsp. enterica serovar Typhi (ST566), and 128 µg/mL against S. enteritidis, S. enterica subsp. enterica serovar Typhi ATCC 6539 (STS). Compounds 1, 2, 4, and 5 have bactericidal effects (MBC/MIC ≤ 4) against the tested Salmonella strains, except for compound 4, which is bacteriostatic to STM with a MBC/MIC value of 16.

一种新的蒽醌，1,6-二羟基-2-羟甲基-5-甲氧基-9,10-蒽二酮（1），以及四种已知的化合物，包括1,2-二甲氧基蒽醌（2），吗啉酮5-甲醚（3）），苦参碱（4）和fraxidin（5）是从巴戟天茎皮的二氯甲烷提取物中分离得到的。通过分析1D和2D NMR，IR和质谱图来完成结构阐明。化合物1，2，4和5分别对五种测试沙门氏菌株。确定最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。结果表明，这四种化合物具有不同的抗菌活性，MIC值为8至256 µg / mL。在这四种化合物中，观察到化合物4对肠沙门氏菌亚种的最佳活性。肠型鼠伤寒杆菌（STM），MIC值为8 µg / mL。化合物1对五种沙门氏菌菌株具有选择性的抗菌活性，相对于STM的MIC为16 µg / mL，针对肠炎沙门氏菌（STE）的MIC为32 µg / mL，针对肠炎沙门氏菌的亚种为64 µg / mL 。小肠血清型伤寒（ST）和肠炎沙门氏菌。肠炎沙门伤寒（ST566），以及对128μg/ mL的肠炎沙门氏菌，肠道沙门氏菌亚种。肠血清型Typhi ATCC 6539（STS）。化合物1，2，4，和5具有针对所测试的杀菌作用（MBC / MIC≤4）沙门氏菌株，除了化合物4，其是抑菌到STM与16的MBC / MIC值。