Abstract

Resveratrol (RES) is a naturally occurring product with numerous biological activities. Despite its potential benefits, its use is limited due to its low aqueous stability and solubility in its native form. The porous sol–gel silica materials which are able to entrap different organic molecules represent new studied release carriers. The aim of this work was to generate a solid matrix to encapsulate RES ensuring protection, increased solubility and release in solutions. A non-toxic ingredient, namely β-cyclodextrin (β-CD), able to form inclusion complexes (ICs) with RES has been used. Ecological formulations have been processed by entrapping the RES containing ICs in silica matrices obtained from a silica colloidal sol by the aqueous route of the sol–gel method. Characterization methods (DSC, FTIR, UV–Vis, fluorescence studies, SEM) have evidenced the presence of RES–β-CD inclusion complex in the silica powder, RES stability in the matrix and its release in aqueous and organic solutions, and the morphology of the carrier. An evaluation of the antioxidant activity of RES in the present formulation was performed by the chemiluminescence assay and RES release profile in aqueous solutions was obtained by HPLC–MS. The resulted materials can find applications in different domains.

Graphic abstract

中文翻译：

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用于改善白藜芦醇在水性环境中的稳定性和释放的生态配方

摘要

白藜芦醇（RES）是具有多种生物活性的天然产物。尽管具有潜在的好处，但是由于其低的水稳定性和天然形式的溶解性而限制了其使用。能够捕获不同有机分子的多孔溶胶-凝胶二氧化硅材料代表了新研究的释放载体。这项工作的目的是生成一个固体基质来封装RES，以确保保护，增加溶解度和在溶液中释放。使用了能够与RES形成包合物（ICs）的无毒成分，即β-环糊精（β-CD）。通过将含有胶体的RES截留在硅胶基质中（通过溶胶-凝胶法的水相路线）而获得的硅胶基质中，可以处理生态制剂。表征方法（DSC，FTIR，UV-Vis，荧光研究，SEM）证明了二氧化硅粉末中存在RES-β-CD包合物，基质中的RES稳定性及其在水溶液和有机溶液中的释放，以及载体的形态。通过化学发光分析评估了本制剂中RES的抗氧化活性，并通过HPLC-MS获得了RES在水溶液中的释放曲线。生成的材料可以在不同领域中找到应用。

图形摘要