Several nontraditional risk factors have been the focus of research in an attempt to understand the disproportionately high cardiovascular morbidity and mortality in chronic kidney disease (CKD) and end-stage kidney disease (ESKD) populations. One such category of risk factors is cardiovascular autonomic dysfunction. Its true prevalence in the CKD/ESKD population is unknown but existing evidence suggests it is common. Due to lack of standardized diagnostic and treatment options, this condition remains undiagnosed and untreated in many patients. In this review, we discuss current evidence pointing toward the role of autonomic nervous system (ANS) dysfunction in CKD, building off of crucial historical evidence and thereby highlighting the areas in need for future research interest.

中文翻译：

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慢性肾病和终末期肾病的心血管自主神经系统功能障碍：互补力的破坏。

一些非传统危险因素一直是研究的重点，试图了解慢性肾病（CKD）和终末期肾病（ESKD）人群中不成比例的高心血管发病率和死亡率。其中一类危险因素是心血管自主神经功能障碍。其在 CKD/ESKD 人群中的真实患病率尚不清楚，但现有证据表明其很常见。由于缺乏标准化的诊断和治疗方案，许多患者的这种情况仍未得到诊断和治疗。在这篇综述中，我们讨论了当前关于自主神经系统 (ANS) 功能障碍在 CKD 中的作用的证据，以关键的历史证据为基础，从而突出了未来研究兴趣所需的领域。