Introduction: The purpose of this retrospective study was to compare the effects of two different modalities of administration of the neuro psycho physical optimization (NPPO) neuromodulation treatment, applied with radio electric asymmetric conveyer (REAC) biotechnology devices. Both the modalities are aimed at improving the strategies to deal with and optimize the allostatic response to environmental stressors and exposome. This allows to reduce the dysfunctional adaptive behavior patterns, which underlie many neuropsychological symptoms and pathologies, and to improve the symptoms of depression, anxiety and stress.
Materials and Methods: From a population of subjects experiencing at least two of the three symptoms depression, anxiety and stress, the selection of pre and post-treatment Depression, Anxiety, Stress 21 items scale (DASS 21) data was made proceeding with a reverse chronological recruitment mechanism, until reaching 150 subjects for each of the 2 groups. The first group was treated with the neuro psycho physical optimization treatment (NPPO), which is the punctiform modality of administration on the auricle pavilion, and the second group was treated with the neuro psycho physical optimization treatment, which is the area modality of administration applied by the planar probe on the cervicobrachial area (NPPO-CB).
Results: The Wilcoxon signs test confirmed the differences in scores in pre and post-treatment DASS-21. The comparison between the two groups data and the comparison across groups data showed that NPPO and NPPO-CB have the same efficacy in reducing the symptoms of depression, anxiety and stress, after a single treatment cycle. Statistical significance was set at p < 0.05.
Discussion: This is the first efficacy descriptive comparison between the two different modalities of administration of the NPPO treatment, as different options for the same clinical indication.

Keywords: neuromodulation, noninvasive neurostimulation, behavioral disorders, DASS-21


中文翻译：

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REAC 在抑郁、焦虑和压力方面的神经调节治疗。比较回顾性研究

简介：这项回顾性研究的目的是比较两种不同方式的神经心理物理优化 (NPPO) 神经调节治疗的效果，这些治疗方式与无线电电不对称输送 (REAC) 生物技术设备一起应用。这两种模式都旨在改进策略以处理和优化对环境压力源和暴露的异态反应。这可以减少功能失调的适应行为模式，这是许多神经心理症状和病理的基础，并改善抑郁、焦虑和压力的症状。
材料和方法：从经历抑郁、焦虑和压力三种症状中的至少两种的受试者群体中，选择治疗前和治疗后的抑郁、焦虑、压力 21 项量表 (DASS 21) 数据，采用逆时间顺序招募机制，直到 2 组中的每组达到 150 名受试者。第一组采用神经心理物理优化治疗（NPPO），即耳廓点状给药方式，第二组采用神经心理物理优化治疗，即区域给药方式通过颈臂区域的平面探头 (NPPO-CB)。
结果：Wilcoxon 标志测试证实了治疗前和治疗后 DASS-21 的分数差异。两组数据的比较和组间数据的比较表明，NPPO和NPPO-CB在单个治疗周期后在减轻抑郁、焦虑和压力症状方面具有相同的功效。统计学显着性设定为 p < 0.05。
讨论：这是 NPPO 治疗的两种不同给药方式之间的首次疗效描述性比较，作为相同临床适应症的不同选择。

关键词：神经调节，无创神经刺激，行为障碍，DASS-21