This parallel randomized controlled trial aimed to evaluate the effect of acceptance and commitment therapy (ACT) focused on disrupting repetitive negative thinking (RNT) versus a waitlist control (WLC) in the treatment of depression and generalized anxiety disorder (GAD). Forty-eight participants with a main diagnosis of depression and/or GAD were allocated by means of simple randomization to a 2-session RNT-focused ACT intervention or to the WLC. The primary outcomes were emotional symptoms as measured by the Depression, Anxiety, and Stress Scales-21. Process outcomes included ACT- and RNT-related measures: general RNT, experiential avoidance, cognitive fusion, values, and generalized pliance. At the 1-month follow-up, linear mixed effects models showed that the intervention was efficacious in reducing emotional symptoms (d = 2.42, 95% confidence interval [1.64, 3.19]), with 94.12% of participants in the RNT-focused ACT condition showing clinically significant change in the Depression, Anxiety, and Stress Scales-21 total scores versus 9.09% in the WLC condition (70% vs. 8% in intention-to-treat analysis). The intervention effects were maintained at the 3-month follow-up. No adverse events were found. A very brief RNT-focused ACT intervention was highly effective in the treatment of depression and GAD. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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针对抑郁症和广泛性焦虑症的两阶段重复，消极思考为重点的接受和承诺治疗（ACT）方案的疗效：一项随机的候补对照试验。

这项平行的随机对照试验旨在评估接受和承诺治疗（ACT）在抑郁和广义焦虑症（GAD）治疗中的作用，该研究的重点是破坏重复性负面思维（RNT）与候补名单对照（WLC）。通过简单随机分配的方法，将主要诊断为抑郁和/或GAD的48位参与者分配给2疗程，以RNT为中心的ACT干预或WLC。主要结果是通过抑郁，焦虑和压力量表21测得的情绪症状。过程结果包括与ACT和RNT相关的度量：一般RNT，体验回避，认知融合，价值和广义依从性。在为期1个月的随访中，线性混合效应模型显示干预措施可有效减轻情绪症状（d = 2.42，95％的置信区间[1.64，3.19]），其中以RNT为中心的ACT病患中94.12％的受试者表现出抑郁，焦虑和压力量表21总得分的临床显着变化，而WLC病患的总得分为9.09％（70％）与意向治疗分析中的8％相比）。在三个月的随访中维持干预效果。未发现不良事件。以RNT为中心的非常简短的ACT干预对抑郁症和GAD的治疗非常有效。（PsycINFO数据库记录（c）2020 APA，保留所有权利）。在三个月的随访中维持干预效果。未发现不良事件。以RNT为中心的非常简短的ACT干预对抑郁症和GAD的治疗非常有效。（PsycINFO数据库记录（c）2020 APA，保留所有权利）。在三个月的随访中维持干预效果。未发现不良事件。以RNT为中心的非常简短的ACT干预对抑郁症和GAD的治疗非常有效。（PsycINFO数据库记录（c）2020 APA，保留所有权利）。