OBJECTIVE Preventive interventions for postpartum depression (PPD) are critical for women at elevated risk of PPD. Mindfulness based cognitive therapy - perinatal depression (MBCT-PD) is a preventive intervention that has been shown to reduce risk for PPD in women with a prior history of depression. The objective of this clinical trial is to examine two potential mechanisms of action of MBCT-PD, emotion regulation and cognitive control, using behavioral and neuroimaging methods. METHOD This baseline protocol describes a randomized control trial (RCT) with two arms, MBCT-PD and treatment as usual (TAU). We plan on enrolling 74 females with a prior history of a major depressive episode, with 37 participants randomized to each arm. Participants in the MBCT-PD arm will receive MBCT-PD during pregnancy, and the TAU group will receive standard prenatal care. All participants will complete the Center for Epidemiological Studies Depression Scale - Revised (CESD-R), Emotion Regulation Questionnaire (ERQ), and classic Stroop task at multiple points from pregnancy through six months postpartum. Participants will also complete an fMRI scan at six weeks postpartum. RESULTS All primary outcomes are collected at six weeks postpartum. Primary behavioral outcomes include: depressive symptoms on the CESD-R, cognitive reappraisal on the ERQ, and Stroop task performance. In parallel, the primary neurobiological outcomes include whole-brain activation during fMRI tasks when participants 1) regulate emotional responding and 2) engage cognitive control. CONCLUSIONS This results of this innovative RCT will help identify potential behavioral and neurobiological mechanisms of action of preventive interventions for PPD for in-depth examination in larger scale RCTs. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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怀孕期间基于正念的认知疗法的机械研究方案。

目的产后抑郁症（PPD）的预防性干预对罹患PPD风险较高的女性至关重要。基于正念的认知疗法-围产期抑郁症（MBCT-PD）是一项预防性干预措施，已被证明可以降低患有抑郁症的既往史女性的PPD风险。这项临床试验的目的是使用行为和神经影像学方法研究MBCT-PD的两种潜在作用机制：情绪调节和认知控制。方法该基线方案描述了一个随机对照试验（RCT），该试验有两个组，MBCT-PD和常规治疗（TAU）。我们计划招募74名具有重大抑郁发作史的女性，每组随机分配37名参与者。MBCT-PD小组的参与者在怀孕期间将接受MBCT-PD，TAU组将接受标准的产前护理。所有参与者将在怀孕至产后六个月的多个时间点完成流行病学研究中心抑郁量表（修订版）（CESD-R），情绪调节问卷（ERQ）和经典Stroop任务。参与者还将在产后六周完成功能磁共振成像扫描。结果所有主要结果均在产后六周收集。主要的行为结果包括：CESD-R上的抑郁症状，ERQ上的认知再评估以及Stroop任务表现。同时，当参与者1）调节情绪反应和2）进行认知控制时，主要的神经生物学结果包括在fMRI任务期间全脑激活。结论这项创新性RCT的结果将有助于确定预防性干预PPD的潜在行为和神经生物学作用机制，以便在大规模RCT中进行深入检查。（PsycInfo数据库记录（c）2020 APA，保留所有权利）。