OBJECTIVE Higher affect variability (the extent to which individuals vary in their affect over time) has been associated with poorer health indicators, but associations with inflammation are less well understood. The purpose of the present study was to examine whether affect variability was associated with inflammation in ways consistent with the stability theory or the fragile positive affect theory, and whether associations were linear or nonlinear. METHOD In a racially diverse sample (N = 231; Aged 25-65; 65% female; 62% Black; 25% Hispanic), we examined whether positive affect (PA) and negative affect (NA) variability exhibited linear or quadratic associations with circulating inflammatory cytokines (a composite measure comprised of IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ), and C-reactive protein (CRP) and whether person-mean affect moderated these associations. Affective states were assessed using ecological momentary assessments (EMAs) 5 times per day for 2 weeks, with a blood draw at the end of the EMA period. Individual standard deviations of affective states indexed affect variability. RESULTS A quadratic association indicated that moderate NA variability was associated with lower CRP. There was evidence of significant moderation by linear associations with PA only: For those with higher person-mean PA, PA variability was positively associated with the cytokine composite. Both person-mean PA and person-mean NA moderated quadratic associations, such that for those with high person-mean affect, both high and low affect variability was associated with systemic inflammation. CONCLUSION Results are in line with fragile affect theory suggesting that associations between affect variability and health indicators may vary by person-mean affect. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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影响中年成年人的变异性和炎症标志物。

目的较高的情绪变异性（个体随时间变化的影响程度）与较差的健康指标相关，但与炎症的相关性尚不清楚。本研究的目的是检查影响变异性是否以与稳定性理论或脆弱的积极影响理论相一致的方式与炎症相关，以及关联是线性的还是非线性的。方法在一个种族差异样本中（N = 231；年龄在25-65岁；女性65％；黑人62％；西班牙裔25％），我们检查了正向影响力（PA）和负向影响力（NA）呈线性或二次相关性。循环炎症细胞因子（由IL-1β，IL-4，IL-6，IL-8，IL-10，TNF-α，IFN-γ组成的综合指标），以及C反应蛋白（CRP）以及人均收入是否影响了这些关联。每天两次使用生态瞬时评估（EMA）评估情感状态，持续2周，并在EMA期结束时抽血。索引的情感状态的各个标准偏差会影响变异性。结果二次关联表明适度的NA变异与较低的CRP相关。有证据表明仅通过线性关联与PA有显着的调节作用：对于具有较高人均PA的患者，PA变异与细胞因子复合物呈正相关。人均PA和人均NA均能调节二次关联，因此对于人均影响较高的人群，影响的高低均与全身性炎症相关。结论结果与脆弱的情感理论一致，表明情感变异性与健康指标之间的关联可能因人均情感而异。（PsycInfo数据库记录（c）2020 APA，保留所有权利）。