Worldwide prevalence of neural tube defects is between 1.2 and 124.1 per 10 000 live births. This study analyzes risk factors linked with neural tube defects. The study focused on the Surveillance and Monitoring Programs of Congenital Anomalies databases in Bogota and Cali. Births were monitored between 2001 and 2018. Liveborn or stillborn with neural tube defects were defined as cases, using a case-control ratio of 1:4. Paternal age, folic acid supplementation, birth weight, urban or rural origin, maternal and paternal studies, and socioeconomic levels were analyzed. Across the 215 730 births monitored, 147 cases with a rate of 6.82/10 000 live births were found (6.79-6.85). In isolated cases, lower birth weight had a P <.01. Paternal age >45 years showed an odds ratio (OR) of 4.24 (1.54-11.65), socioeconomic status 1 and 2, OR of 2.49 (1.63-3.82), maternal primary schooling or lower OR 2.61 (1.28-5.31), and housing in urban areas OR 2.4 (1.4-4.09).

世界范围内神经管缺陷的患病率为每 10 000 名活产儿 1.2 至 124.1 人。本研究分析了与神经管缺陷相关的风险因素。该研究的重点是波哥大和卡利的先天性异常数据库的监测和监测计划。在 2001 年至 2018 年期间对出生情况进行了监测。使用 1:4 的病例对照比将患有神经管缺陷的活产或死产定义为病例。分析了父亲年龄、叶酸补充、出生体重、城市或农村出身、母亲和父亲的研究以及社会经济水平。在监测的 215 730 例新生儿中，发现了 147 例，活产率为 6.82/10 000 (6.79-6.85)。在个别情况下，较低的出生体重有一个P<.01. 父亲年龄 > 45 岁的优势比 (OR) 为 4.24 (1.54-11.65)，社会经济地位为 1 和 2，OR 为 2.49 (1.63-3.82)，母亲小学文化程度或更低 OR 2.61 (1.28-5.31)，以及住房在市区或 2.4 (1.4-4.09)。