Application of CRISPR/Cas9 System to Reverse ABC-Mediated Multidrug Resistance,Bioconjugate Chemistry

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Application of CRISPR/Cas9 System to Reverse ABC-Mediated Multidrug Resistance
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-01-03 , DOI: 10.1021/acs.bioconjchem.0c00627
Wei Wang ₁ , Ze Liang ₁ , Pengfei Ma ₁ , Qi Zhao ₂ , Mengyuan Dai ₃ , Jie Zhu ₃ , Xu Han ₁ , Hong Xu ₄ , Qingyan Chang ₅ , Yuhong Zhen ₁

Affiliation

Multidrug resistance (MDR) is the main obstacle in cancer chemotherapy. ATP-binding cassette (ABC) transporters can transport a wide range of antitumor drugs out of cells, which is the most common reason in the development of resistance to drugs. Currently, various therapeutic strategies are used to reverse MDR, among which CRISPR/Cas9 gene editing technique is expected to be an effective way. Here, we reviewed the research progress of reversing ABC-mediated drug resistance by CRISPR/Cas9 system.

中文翻译：

CRISPR/Cas9系统在逆转ABC介导的多药耐药中的应用

多药耐药（MDR）是癌症化疗的主要障碍。ATP 结合盒 (ABC) 转运蛋白可以将多种抗肿瘤药物转运出细胞，这是产生耐药性的最常见原因。目前，多种治疗策略被用于逆转MDR，其中CRISPR/Cas9基因编辑技术有望成为一种有效的方法。本文综述了CRISPR/Cas9系统逆转ABC介导的耐药性的研究进展。

更新日期：2021-01-20

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