Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evaluate the lifetime of the introduced surface layer, which is an important aspect affecting how a biomaterial will interact with a cellular environment both in the short and in the long term. This study evaluated the surface layer stability in vitro in buffer solution of materials produced from poly(lactic-co-glycolic acid) (50:50) and polycaprolactone modified by hydrolysis and/or grafting of hydrophilic polymers using grafting from approaches. The data presented in this study highlight the shortcomings of using model substrates (e.g., spun-coated films) rather than disks, particles, and scaffolds. It also illustrates how similar surface modification strategies in some cases result in very different lifetimes of the surface layer, thus emphasizing the need for these studies as analogies cannot always be drawn.

中文翻译：

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表面改性聚酯生物材料表层稳定性评价

生物材料的表面改性是一种用于改善细胞和体内结果的策略。然而，大多数研究并没有评估引入的表面层的寿命，这是影响生物材料在短期和长期与细胞环境相互作用的一个重要方面。本研究评估了体外表层稳定性在由聚（乳酸 - 共 - 乙醇酸）（50:50）和聚己内酯生产的材料的缓冲溶液中，通过水解和/或使用接枝方法接枝亲水聚合物而改性。本研究中提供的数据突出了使用模型基材（例如，旋涂薄膜）而不是圆盘、颗粒和支架的缺点。它还说明了在某些情况下相似的表面改性策略如何导致表面层的寿命非常不同，因此强调了这些研究的必要性，因为不能总是进行类比。