Abstract

A facile one-pot sequential four-component synthesis of highly substituted trispiro heterocyclic system involving [3 + 2]-cycloaddition of azomethine ylides as the key step is described. The protocol provides a mild reaction condition, high yield of the products, high regioselectivity, and operational simplicity to assemble complex structural entity in a single operation. The structure of the product was confirmed by spectroscopic techniques, elemental and high-resolution mass spectrum analysis.

中文翻译：

---

容易获得的高度取代的三螺杂环化合物–通过顺序多组分反应合成新型吡唑并-1,4-二氧杂-螺[4,5]癸烷接枝的螺-氧代吲哚并吡咯烷

摘要

描述了一种简单的一锅顺序四组分合成高度取代的三螺杂环系统的步骤，该方法涉及偶氮甲亚胺的[3 + 2]-环加成反应为关键步骤。该方案提供了温和的反应条件，高收率的产品，高的区域选择性和操作简便性，可在一次操作中组装复杂的结构实体。通过光谱技术，元素和高分辨率质谱分析确认了产物的结构。