Abstract

Ruthenium catalyzed oxidative dearomatization-alkoxylation of N-Boc indoles for the synthesis of 2-alkoxyindolin-3-ones was described. The N-Boc indoles can be transformed into 2-alkoxyindolin-3-ones with RuCl₃·3H₂O as catalyst and tert-butyl hydroperoxide (TBHP, 3.0 equiv) as oxidant in dichloromethane/alcohol. Furtherly, the mechanism had been proposed on the basis of control experiments and isolation of intermediates.

中文翻译：

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Ru催化N-Boc吲哚的氧化脱芳香化-烷氧基化

摘要

描述了钌催化的N -Boc吲哚的氧化脱芳香化-烷氧基化反应，用于合成2-烷氧基吲哚-3-酮。所述Ñ -Boc吲哚可以转化成2- alkoxyindolin -3-酮用的RuCl ₃ ·3H ₂ O作为催化剂和叔丁基过氧化氢（TBHP，3.0当量）的二氯甲烷/醇的氧化剂。此外，在控制实验和中间体分离的基础上提出了该机理。