ABSTRACT

Chitosan (CS) is a biopolymer that presents remarkable biomedical applications. Here we report on the fluorescence study of water-soluble CS nanoparticles obtained by hydrothermal treatment at different temperatures and exposure times using hydrochloric acid as solvent. Average particle size varied from 1.69 μm to 112 nm for tested conditions. The fluorescence quantum yield of these CS NPs was increased by up to 75 times. Methotrexate (MTX) was incorporated in to CS NPs and our outcomes pointed out that the incorporation efficiency of MTX in to CS-NPs was 72.90%, and 25.30% (w/w) of the incorporated MTX was released in 96 h.

摘要

壳聚糖（CS）是一种生物聚合物，具有出色的生物医学应用。在这里，我们报告了通过使用盐酸作为溶剂在不同温度和暴露时间下进行水热处理而获得的水溶性CS纳米粒子的荧光研究。在测试条件下，平均粒径从1.69μm到112 nm不等。这些CS NP的荧光量子产率提高了75倍。甲氨蝶呤（MTX）被并入CS NP中，我们的结果指出，MTX在CS-NP中的掺入效率为72.90％，并在96 h内释放了25.30％（w / w）的MTX。