Paclitaxel-induced peripheral neuropathic pain (PIPNP) is a major therapy- and dose-limiting side effect that is extremely laborious to treat. Resveratrol (Res), with a structure name of 3,5,40-trihydroxystilbene, is a kind of natural polyphenolic chemical with plenty of useful characteristics such as anti-inflammatory, and anti-oxidative stress. However, the impact of Res on PIPNP remains unclear. Therefore, the current study intends to examine the analgesic effect of Res on PIPNP. In the present study, the results revealed that Res could effectively prevent the development of paclitaxel-induced PIPNP in a dose-dependent manner when repeated doses of Res were given during PIPNP induction. This prophylactic effect of Res was involved in inhibited paclitaxel-induced up-regulation of TRPV1 instead of TRPA1 in the dorsal root ganglia. Furthermore, the inhibition of TRPV1 up-regulation by Res may be involved in a phosphorylation of ERK mechanism. In summary, we conclude that Res plays an intriguing role in the prevention of PIPNP and thus may work as a therapeutic compound for treating and preventing PIPNP.

紫杉醇诱发的周围神经性疼痛（PIPNP）是一种主要的治疗和剂量限制性副作用，治疗起来非常费力。白藜芦醇（Res），具有3,5,40-trihydroxystilbene的结构名称，是一种天然的多酚类化学物质，具有许多有用的特性，例如抗炎和抗氧化应激。但是，Res对PIPNP的影响尚不清楚。因此，目前的研究旨在检查Res对PIPNP的镇痛作用。在本研究中，结果表明，当在PIPNP诱导过程中重复给予Res剂量时，Res可以以剂量依赖的方式有效预防紫杉醇诱导的PIPNP的发展。Res的这种预防作用参与了紫杉醇诱导的背根神经节中TRPV1而不是TRPA1的上调。此外，Res对TRPV1上调的抑制作用可能与ERK机制的磷酸化有关。总之，我们得出的结论是，Res在预防PIPNP中起着有趣的作用，因此可以作为治疗和预防PIPNP的治疗性化合物。