Application of natural products for inducing ferroptosis in tumor cells,Biotechnology and Applied Biochemistry

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Application of natural products for inducing ferroptosis in tumor cells
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2021-01-04 , DOI: 10.1002/bab.2096
Zhengxin Wu ₁ , Mengya Zhong _{2,

3} , Yu Liu _{2,

3} , Yubo Xiong _{2,

3} , Zhi Gao ₄ , Jingsong Ma _{2,

3} , Guohong Zhuang ₅ , Xuehui Hong _{2,

3}

Affiliation

Ferroptosis is a regulated cell death pathway based on the deposition of lipid-based reactive oxygen species (L-ROS) in the presence of iron ions. The term was first coined in 2012 by Dixon. Decreased glutathione (GSH) synthesis and low glutathione-dependent antioxidant peroxidase 4 (GPX4) activity are the major causes of ferroptosis. Sensitivity to ferroptosis for example in tumor cells may be further enhanced by high cellular iron concentrations and/or high p53 levels. Therefore, driving ferroptosis in tumor cells could be a new way to treat tumors. Thus far, natural products have played considerable roles in antitumor research and treatment, and some drugs, such as paclitaxel, have proven beneficial in many cancer patients. According to current research, natural products can induce ferroptosis when used alone or in conjunction with other cancer therapies. This review mainly elaborates the main mechanism of ferroptosis and the regulating effects of some natural products on ferroptosis, aiming to create a new space for the research and development of novel anticancer drugs.

中文翻译：

天然产物在诱导肿瘤细胞铁死亡中的应用

铁死亡是一种受调节的细胞死亡途径，它基于在铁离子存在下基于脂质的活性氧 (L-ROS) 的沉积。该术语由 Dixon 于 2012 年首次创造。谷胱甘肽 (GSH) 合成减少和谷胱甘肽依赖性抗氧化过氧化物酶 4 (GPX4) 活性低是铁死亡的主要原因。高细胞铁浓度和/或高 p53 水平可进一步增强对例如肿瘤细胞中铁死亡的敏感性。因此，在肿瘤细胞中驱动铁死亡可能是一种治疗肿瘤的新方法。迄今为止，天然产物在抗肿瘤研究和治疗中发挥了重要作用，一些药物，如紫杉醇，已被证明对许多癌症患者有益。根据目前的研究，当单独使用或与其他癌症疗法结合使用时，天然产物可以诱导铁死亡。本综述主要阐述了铁死亡的主要机制以及部分天然产物对铁死亡的调节作用，旨在为新型抗癌药物的研发开辟新的空间。

更新日期：2021-01-04

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