The purpose of this study is to explore whether a correlation exists between the bacterial load of Borrelia persica in tick-borne relapsing fever (TBRF), established by quantitative real-time PCR, and the development of Jarisch-Herxheimer reaction (JHR) after the initiation of antibiotic treatment. Forty-two blood samples were included in our study. The mean bacterial load, as established by real-time PCR, in patients who developed JHR was significantly greater than in those patients who did not develop JHR (443,293 copies vs. 140,598, p = 0.035). Accordingly, real-time PCR may assist clinicians in identifying patients at higher risk of JHR.

本研究的目的是探讨通过定量实时 PCR 确定的蜱传回归热 (TBRF) 中桃叶疏螺旋体的细菌负荷与感染后 Jarisch-Herxheimer 反应 (JHR) 的发展之间是否存在相关性。开始抗生素治疗。我们的研究中包括了四十二份血液样本。通过实时 PCR 确定，发生 JHR 的患者的平均细菌负荷显着高于未发生 JHR 的患者（443,293 拷贝 vs. 140,598，p = 0.035）。因此，实时 PCR 可以帮助临床医生识别 JHR 风险较高的患者。