Abstract

Anacardic acid is a renewable product extracted, under mild conditions, from the cashew nuts. Its importance is growing with time thanks to various high-value biotechnological applications. In this research, anacardic acid has been used both in pristine form, and as the main component combined with cholesterol, to prepare three different nanoformulations through an environmentally friendly procedure. Physicochemical characterization shown stable and well-shaped spherical nanomorphologies with a mean diameter of about 220 nm. Stability studies in aqueous solution involving different anacardic acid-based formulations at different temperatures allowed to find the optimal combinations for obtaining vesicular nanosystems, the composition of which remains unchanged up to 28 days. These results are promising to refine the development of potential bioactive nanocarriers to be applied in the biomedical and pharmaceutical fields.

Graphic Abstract

中文翻译：

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没食子酸：可持续制备囊泡纳米系统的有前途的基石。

摘要

腰果酸是在温和条件下从腰果中提取的可再生产品。由于各种高价值的生物技术应用，其重要性随着时间的增长而增长。在这项研究中，已以纯净形式和与胆固醇结合的主要成分使用了腰果酸，以环保的方式制备了三种不同的纳米制剂。物理化学表征显示出稳定且形状良好的球形纳米形态，平均直径约为220 nm。在不同温度下涉及不同基于二十碳酸的制剂的水溶液中的稳定性研究允许找到用于获得水泡纳米系统的最佳组合，水泡纳米系统的组成在28天之内保持不变。

图形摘要