This research was aimed at examining the effect of piracetam on behavioral reactions and morphological changes in the brain of adult rats after fractionated gamma irradiation with a total dose of 5 Gy. Fractionated gamma irradiation led to a decrease in freezing behavior in the Open Field and leukopenia. These behavioral and hematological disorders were accompanied by a cell decrease in the cross-sectional area of granular layer of the dentate gyrus, an increase in the number of Fluoro Jade B-positive cells, and an increase in the number of irreversible changes in the cerebral cortex. The administration of piracetam immediately after irradiation for 14 days maintained the freezing behavior at the level of intact animals and decreased in general motor activity. Also, an increase in morphometric parameters and a decrease of neurodegeneration were observed. We found a statistically significant decrease in the number of Fluoro Jade B-positive cells in comparison with the group of irradiated animals. The drug had no leukoprotective effect on laboratory animals, and led to the emergence of inconclusive trends in the alternation of the arms of the T-labyrinth. Piracetam application showed positive behavioral and morphological changes in rodents and might have a neuroprotective effect in brain tissue after gamma irradiation. Since it is the first experiment with piracetam we attempted, this exploratory study serves to provide more insight into the potential neuroprotection activity of piracetam, and following research is necessary.

本研究旨在探讨总剂量为5 Gy的分段伽玛射线照射后，吡拉西坦对成年大鼠行为反应和大脑形态变化的影响。分段伽马射线照射导致开放视野中的冻结行为减少和白细胞减少。这些行为和血液学疾病伴随着齿状回颗粒层横截面积的细胞减少、氟玉B阳性细胞数量的增加以及大脑中不可逆改变数量的增加。皮质。照射后立即给予吡拉西坦 14 天，可将冻结行为维持在完整动物的水平，并降低一般运动活动。此外，还观察到形态参数的增加和神经变性的减少。我们发现与接受辐射的动物组相比，Fluoro Jade B 阳性细胞的数量在统计上显着减少。该药物对实验动物没有白细胞保护作用，并导致 T 型迷宫臂交替出现不确定的趋势。吡拉西坦的应用在啮齿动物中显示出积极的行为和形态变化，并且可能在伽马射线照射后对脑组织具有神经保护作用。由于这是我们尝试的第一个吡拉西坦实验，这项探索性研究有助于更深入地了解吡拉西坦的潜在神经保护活性，后续研究是必要的。