It has been presented the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We aim to discuss the effect of sex-determining region Y-box 2 (SOX2)/lncRNA colon cancer-associated transcript-1 (CCAT1)/microRNA-185-3p (miR-185-3p)/forkhead box protein 3 (FOXP3) on the proliferation and self-renewal ability of CC stem cells. MiR-185-3p, SOX2, CCAT1 and FOXP3 expressions were tested in CC tissues and cells. The relationship between SOX2/CCAT1 expression and clinicopathological features in CC patients was verified. Loss- and gain-of-function investigations were conducted in CD44⁺HeLa cells to discuss biological functions and self-renewal capacity. Finally, the relationships among SOX2, CCAT1, FOXP3 and miR-185-3p were verified. miR-185-3p expression was decreased, while SOX2, CCAT1 and FOXP3 expressions were increased in CC tissues and cells. SOX2 and CCAT1 expressions were linked to tumor size, lymph node metastasis and international federation of gynecology and obstetrics stage of CC. Down-regulating SOX2 or CCAT1 and up-regulating miR-185-3p resulted in inhibition of proliferation, invasion, migration and cell sphere number as well as apoptosis acceleration of CD44⁺HeLa cells. SOX2 could bind to CCAT1 which affected miR-185-3p expression, and FOXP3 was targeted by miR-185-3p.

已经提出了长链非编码 RNA (lncRNA) 在宫颈癌 (CC) 中的作用。我们旨在讨论性别决定区 Y-box 2 (SOX2)/lncRNA 结肠癌相关转录本 1 (CCAT1)/microRNA-185-3p (miR-185-3p)/叉头盒蛋白 3 (FOXP3 ) 对 CC 干细胞的增殖和自我更新能力的影响。在 CC 组织和细胞中测试 MiR-185-3p、SOX2、CCAT1 和 FOXP3 的表达。验证了CC患者SOX2/CCAT1表达与临床病理特征的关系。在 CD44 ^{+中进行了功能丧失和获得的调查}HeLa 细胞讨论生物学功能和自我更新能力。最后，验证了SOX2、CCAT1、FOXP3和miR-185-3p之间的关系。CC组织和细胞中miR-185-3p表达降低，而SOX2、CCAT1和FOXP3表达增加。SOX2和CCAT1的表达与CC的肿瘤大小、淋巴结转移和国际妇产科联合会分期有关。^{下调SOX2或CCAT1和上调miR-185-3p导致CD44 +} HeLa细胞增殖、侵袭、迁移和细胞球数的抑制以及凋亡加速。SOX2 可以与影响 miR-185-3p 表达的 CCAT1 结合，而 FOXP3 被 miR-185-3p 靶向。