Parkinson’s disease (PD) adversely affects information processing and motor performance. The impact of aerobic exercise on modifying the deleterious effects of PD underlying information and motor control processes is not well established. The primary aim of this project was to determine the effects of an 8-week high intensity exercise intervention on information processing and movement execution in individuals with PD. A secondary aim sought to understand the effects of antiparkinsonian medication relative to exercise on motor control processes. Data were collected at baseline (on- and off-medication) and upon completion of the exercise intervention (off-medication). Information processing and motor execution were evaluated via simple and choice reaction time paradigms (SRT and CRT) performed on a mobile device. Neither exercise nor medication impacted information processing or movement execution under the SRT paradigm. However, under CRT, exercise improved movement execution and information processing: total time was significantly reduced from 814 to 747 ms (p < 0.001), reaction time improved from 543 to 502 ms (p < 0.001), movement time improved from 270 to 246 ms (p = 0.01), and movement velocity improved from 28 cm/sec to 30 cm/sec (p = 0.01). Improvements in total time and reaction time in the CRT paradigm persisted 4 and 8 weeks following exercise cessation. Antiparkinsonian medication improved motor execution, but not information processing. The improvement in information processing following aerobic exercise, but not levodopa administration, suggests high intensity exercise may be enhancing neural processing and non-motor pathways outside those impacted by medication. The persistence of symptom improvement despite exercise intervention cessation indicates exercise is a candidate for disease modification. Trial registration: The trial was first registered at ClinicalTrials.gov on 7/10/2012 under registration number NCT01636297.

帕金森氏病（PD）会对信息处理和运动表现产生不利影响。有氧运动对改变PD基础信息和运动控制过程的有害影响的影响尚未很好地确定。该项目的主要目的是确定8周高强度运动干预对PD患者信息处理和运动执行的影响。第二个目的是试图了解抗帕金森病药物相对于运动对运动控制过程的影响。在基线（用药和用药外）和运动干预完成后（用药）收集数据。通过在移动设备上执行的简单选择反应时间范式（SRT和CRT）评估信息处理和电机执行。运动和药物都不会影响SRT范式下的信息处理或运动执行。但是，在CRT下，锻炼可以改善动作执行和信息处理的效果：总时间从814毫秒大幅减少到747毫秒p  <0.001），反应时间从543 ms改善到502 ms（p  <0.001），移动时间从270 ms改善到246 ms（p  = 0.01），移动速度从28 cm / sec改善到30 cm / sec（p = 0.01）。停止运动后4到8周，CRT范例中的总时间和反应时间的改善持续。抗帕金森氏症药物可改善运动功能，但不能改善信息处理能力。有氧运动后而非左旋多巴给药后信息处理的改善表明，高强度运动可能会增强受药物影响的神经处理和非运动途径。尽管运动干预停止，但症状改善的持续性表明运动是疾病改变的候选者。试验注册：该试验最早于2012年7月10日在ClinicalTrials.gov上注册，注册号为NCT01636297。