Abstract

Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at http://mitimpact.css-mendel.it.

中文翻译：

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MitImpact 3：模拟呼吸链亚基的残基相互作用网络

 抽象的

大量证据表明，核基因组和线粒体基因组之间的相互作用确保了 OXPHOS 复合物的有效运作，对生物能学、适应和疾病具有重大影响。它们的相互作用是 MitImpact 在其第三个主要版本中探索的真核细胞的一个迷人而复杂的特征。 MitImpact 扩展了其对人类线粒体基因组所有非同义替换的基因组、临床和功能注释的收集，提供了有关假定的补偿致病性偏差和呼吸链亚基共变氨基酸位点的新信息。它进一步提供了通过分子动力学模拟技术进行能量和结构残基补偿的证据。 MitImpact 可通过 http://mitimpact.css-mendel.it 免费访问。