Abstract

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.

中文翻译：

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基因本体资源：丰富一个金矿

摘要

基因本体联盟 (GOC) 提供了目前最全面的资源，可用于有关基因和基因产物功能的可计算知识。在这里，我们报告了该财团在过去两年中的进展。新的 GO-CAM 注释框架得到了显着改进，我们使用计算模式对模型进行了形式化，以检查和验证快速增长的 2838 个 GO-CAM 存储库。此外，我们描述了多项合作对改进 GO 的影响，并报告 GO 注释数量增加了 10%，注释基因产品增加了 25%，注释了 9,400 多篇新的科学文章。随着项目的成熟，我们将继续努力根据新发现审查旧注释，并保持与其他本体的一致性。因此，审查了来自实验数据的 20 000 个注释，对应于 2.5% 的实验 GO 注释。网站 (http://geneontology.org) 经过重新设计，可以快速访问文档、下载和工具。为了维护准确的资源并支持可追溯性和再现性，我们提供了一个历史档案，涵盖了过去 15 年的 GO 数据，其本体和注释的格式和文件结构一致。