Abstract

MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease.

中文翻译：

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MoonProt 3.0：月光照蛋白质数据库的更新

摘要

MoonProt 3.0（http://moonlightingproteins.org）是一个更新的开放式数据库，其中存储了专家策划的月光蛋白注释。月光蛋白具有由单个多肽链执行的两个或多个生理相关的独特生化或生物物理功能。在此，我们描述了自2018年《核酸研究的数据库问题》上次报告以来数据库的扩展。对于此版本，已注释的蛋白质数量已扩展到500多种蛋白质，并且数十种蛋白质注释已进行了其他更新。信息，包括蛋白质数据库中与2.0版相比更多的结构。新条目包括来自人类，植物和古细菌的更多示例，涉及疾病的更多蛋白质以及具有不同功能组合的蛋白质。