Abstract

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.

中文翻译：

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UniProt：2021 年通用蛋白质知识库

摘要

UniProt 知识库的目标是为用户提供全面、高质量且可免费访问的一组带有功能信息注释的蛋白质序列。在本文中，我们描述了过去两年对该资源所做的重大更新。尽管继续努力减少蛋白质组水平的序列冗余，但 UniProtKB 中的序列数量已增加至约 1.9 亿。我们采用了评估蛋白质组完整性和质量的新方法。我们继续从文献中提取详细注释，添加到已审阅的条目中，并使用自动化系统（例如新实施的基于关联规则的注释器（ARBA））提供的注释补充未审阅的条目中的注释。我们开发了一个基于信用的出版物提交界面，允许社区为 UniProt 条目贡献出版物和注释。我们描述了 UniProtKB 如何通过专家整理相关条目来应对 COVID-19 大流行，这些条目通过专用门户迅速提供给研究界。UniProt 资源可在 CC-BY (4.0) 许可下通过网站 https://www.uniprot.org/ 获取。