Abstract

The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that provides information on drug-gene interactions and druggable genes from publications, databases, and other web-based sources. Drug, gene, and interaction data are normalized and merged into conceptual groups. The information contained in this resource is available to users through a straightforward search interface, an application programming interface (API), and TSV data downloads. DGIdb 4.0 is the latest major version release of this database. A primary focus of this update was integration with crowdsourced efforts, leveraging the Drug Target Commons for community-contributed interaction data, Wikidata to facilitate term normalization, and export to NDEx for drug-gene interaction network representations. Seven new sources have been added since the last major version release, bringing the total number of sources included to 41. Of the previously aggregated sources, 15 have been updated. DGIdb 4.0 also includes improvements to the process of drug normalization and grouping of imported sources. Other notable updates include the introduction of a more sophisticated Query Score for interaction search results, an updated Interaction Score, the inclusion of interaction directionality, and several additional improvements to search features, data releases, licensing documentation and the application framework.

中文翻译：

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药物-基因相互作用数据库 (DGIdb 4.0) 与开放众包工作的整合

 抽象的

药物基因相互作用数据库（DGIdb，www.dgidb.org）是一个网络资源，提供来自出版物、数据库和其他网络来源的药物基因相互作用和可药物基因的信息。药物、基因和相互作用数据被标准化并合并到概念组中。用户可以通过简单的搜索界面、应用程序编程接口 (API) 和 TSV 数据下载来获取此资源中包含的信息。 DGIdb 4.0 是该数据库的最新主要版本。本次更新的主要重点是与众包工作的集成，利用 Drug Target Commons 获取社区贡献的交互数据，利用 Wikidata 促进术语标准化，并导出到 NDEx 进行药物基因交互网络表示。自上次主要版本发布以来，已添加 7 个新源，使包含的源总数达到 41 个。在之前汇总的源中，有 15 个已更新。 DGIdb 4.0 还包括对药物标准化和进口来源分组过程的改进。其他值得注意的更新包括为交互搜索结果引入更复杂的查询分数、更新的交互分数、包含交互方向性，以及对搜索功能、数据发布、许可文档和应用程序框架的一些其他改进。