Abstract

The MobiDB database (URL: https://mobidb.org/) provides predictions and annotations for intrinsically disordered proteins. Here, we report recent developments implemented in MobiDB version 4, regarding the database format, with novel types of annotations and an improved update process. The new website includes a re-designed user interface, a more effective search engine and advanced API for programmatic access. The new database schema gives more flexibility for the users, as well as simplifying the maintenance and updates. In addition, the new entry page provides more visualisation tools including customizable feature viewer and graphs of the residue contact maps. MobiDB v4 annotates the binding modes of disordered proteins, whether they undergo disorder-to-order transitions or remain disordered in the bound state. In addition, disordered regions undergoing liquid-liquid phase separation or post-translational modifications are defined. The integrated information is presented in a simplified interface, which enables faster searches and allows large customized datasets to be downloaded in TSV, Fasta or JSON formats. An alternative advanced interface allows users to drill deeper into features of interest. A new statistics page provides information at database and proteome levels. The new MobiDB version presents state-of-the-art knowledge on disordered proteins and improves data accessibility for both computational and experimental users.

中文翻译：

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MobiDB：2021 年本质上无序的蛋白质

 抽象的

MobiDB 数据库（URL：https://mobidb.org/）提供本质上无序蛋白质的预测和注释。在这里，我们报告了 MobiDB 第 4 版中在数据库格式方面的最新进展，包括新颖的注释类型和改进的更新过程。新网站包括重新设计的用户界面、更有效的搜索引擎和用于编程访问的高级 API。新的数据库模式为用户提供了更大的灵活性，并简化了维护和更新。此外，新的入口页面提供了更多可视化工具，包括可定制的特征查看器和残留物接触图的图表。 MobiDB v4 注释了无序蛋白质的结合模式，无论它们经历无序到有序的转变还是在结合状态下保持无序。此外，还定义了经历液-液相分离或翻译后修饰的无序区域。集成信息以简化的界面呈现，可实现更快的搜索，并允许以 TSV、Fasta 或 JSON 格式下载大型定制数据集。另一种高级界面允许用户更深入地研究感兴趣的功能。新的统计页面提供数据库和蛋白质组级别的信息。新的 MobiDB 版本提供了有关无序蛋白质的最先进知识，并提高了计算和实验用户的数据可访问性。