Abstract

An updated Lnc2Cancer 3.0 (http://www.bio-bigdata.net/lnc2cancer or http://bio-bigdata.hrbmu.edu.cn/lnc2cancer) database, which includes comprehensive data on experimentally supported long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with human cancers. In addition, web tools for analyzing lncRNA expression by high-throughput RNA sequencing (RNA-seq) and single-cell RNA-seq (scRNA-seq) are described. Lnc2Cancer 3.0 was updated with several new features, including (i) Increased cancer-associated lncRNA entries over the previous version. The current release includes 9254 lncRNA-cancer associations, with 2659 lncRNAs and 216 cancer subtypes. (ii) Newly adding 1049 experimentally supported circRNA-cancer associations, with 743 circRNAs and 70 cancer subtypes. (iii) Experimentally supported regulatory mechanisms of cancer-related lncRNAs and circRNAs, involving microRNAs, transcription factors (TF), genetic variants, methylation and enhancers were included. (iv) Appending experimentally supported biological functions of cancer-related lncRNAs and circRNAs including cell growth, apoptosis, autophagy, epithelial mesenchymal transformation (EMT), immunity and coding ability. (v) Experimentally supported clinical relevance of cancer-related lncRNAs and circRNAs in metastasis, recurrence, circulation, drug resistance, and prognosis was included. Additionally, two flexible online tools, including RNA-seq and scRNA-seq web tools, were developed to enable fast and customizable analysis and visualization of lncRNAs in cancers. Lnc2Cancer 3.0 is a valuable resource for elucidating the associations between lncRNA, circRNA and cancer.

中文翻译：

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Lnc2Cancer 3.0：基于RNA-seq和scRNA-seq数据的实验支持lncRNA / circRNA癌症关联和网络工具的更新资源

摘要

更新的Lnc2Cancer 3.0（http://www.bio-bigdata.net/lnc2cancer或http://bio-bigdata.hrbmu.edu.cn/lnc2cancer）数据库，其中包含有关实验支持的长非编码RNA的全面数据（ lncRNA和环状RNA（circRNA）与人类癌症相关。此外，还介绍了用于通过高通量RNA测序（RNA-seq）和单细胞RNA-seq（scRNA-seq）分析lncRNA表达的Web工具。Lnc2Cancer 3.0更新了几个新功能，其中包括：（i）与以前版本相比，与癌症相关的lncRNA条目增加了。当前版本包括9254个lncRNA-癌症关联，2659个lncRNA和216个癌症亚型。（ii）新增加了1049个实验支持的circRNA-癌症关联，其中包括743个circRNA和70个癌症亚型。（iii）实验支持的与癌症相关的lncRNA和circRNA的调控机制，包括microRNA，转录因子（TF），遗传变异，甲基化和增强子。（iv）追加实验支持的与癌症相关的lncRNA和circRNA的生物学功能，包括细胞生长，凋亡，自噬，上皮间充质转化（EMT），免疫力和编码能力。（v）包括与癌症相关的lncRNA和circRNA在转移，复发，循环，耐药性和预后方面的实验支持的临床相关性。此外，还开发了两个灵活的在线工具，包括RNA-seq和scRNA-seq网络工具，可以对癌症中的lncRNA进行快速且可定制的分析和可视化。Lnc2Cancer 3.0是阐明lncRNA之间关联的宝贵资源，