Abstract

The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources. The existing FANTOM5 human and mouse miRNA atlas was supplemented with rat, dog, and chicken datasets. The sixth (latest) edition of the FANTOM project was launched to assess the function of human long non-coding RNAs (lncRNAs). From its creation until 2020, FANTOM6 has contributed to the research community a large dataset generated from the knock-down of 285 lncRNAs in human dermal fibroblasts; this is followed with extensive expression profiling and cellular phenotyping. Other updates to the FANTOM resource includes the reprocessing of the miRNA and promoter atlases of human, mouse and chicken with the latest reference genome assemblies. To facilitate the use and accessibility of all above resources we further enhanced FANTOM data viewers and web interfaces. The updated FANTOM web resource is publicly available at https://fantom.gsc.riken.jp/.

中文翻译：

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FANTOM进入20年：转录组图谱的扩展和非编码RNA的功能注释

摘要

哺乳动物基因组（FANTOM）联盟的功能注释在过去20年中继续为寻求了解哺乳动物基因组的转录组和转录调控提供广泛的资源。为了与研究社区共享这些资源，FANTOM Web界面和数据库正在定期更新，增强和扩展以新的数据类型。近年来，FANTOM联盟的工作主要集中在创建新的非编码RNA数据集和资源上。现有的FANTOM5人类和小鼠miRNA地图集补充有大鼠，狗和鸡的数据集。FANTOM项目的第六个（最新）版本启动，以评估人类长非编码RNA（lncRNA）的功能。从创建到2020年，FANTOM6为研究界做出了巨大贡献，它是由人类皮肤成纤维细胞中285个lncRNA的敲除产生的大型数据集。然后进行广泛的表达谱分析和细胞表型分析。FANTOM资源的其他更新包括使用最新的参考基因组程序对人，小鼠和鸡的miRNA和启动子图谱进行再处理。为了促进上述所有资源的使用和可访问性，我们进一步增强了FANTOM数据查看器和Web界面。更新的FANTOM Web资源可从https://fantom.gsc.riken.jp/公开获得。FANTOM资源的其他更新包括使用最新的参考基因组程序对人，小鼠和鸡的miRNA和启动子图谱进行再处理。为了促进上述所有资源的使用和可访问性，我们进一步增强了FANTOM数据查看器和Web界面。更新的FANTOM Web资源可从https://fantom.gsc.riken.jp/公开获得。FANTOM资源的其他更新包括使用最新的参考基因组程序对人，小鼠和鸡的miRNA和启动子图谱进行再处理。为了促进上述所有资源的使用和可访问性，我们进一步增强了FANTOM数据查看器和Web界面。更新的FANTOM Web资源可从https://fantom.gsc.riken.jp/公开获得。