Abstract

The BRENDA enzyme database (https://www.brenda-enzymes.org), established in 1987, has evolved into the main collection of functional enzyme and metabolism data. In 2018, BRENDA was selected as an ELIXIR Core Data Resource. BRENDA provides reliable data, continuous curation and updates of classified enzymes, and the integration of newly discovered enzymes. The main part contains >5 million data for ∼90 000 enzymes from ∼13 000 organisms, manually extracted from ∼157 000 primary literature references, combined with information of text and data mining, data integration, and prediction algorithms. Supplements comprise disease-related data, protein sequences, 3D structures, genome annotations, ligand information, taxonomic, bibliographic, and kinetic data. BRENDA offers an easy access to enzyme information from quick to advanced searches, text- and structured-based queries for enzyme-ligand interactions, word maps, and visualization of enzyme data. The BRENDA Pathway Maps are completely revised and updated for an enhanced interactive and intuitive usability. The new design of the Enzyme Summary Page provides an improved access to each individual enzyme. A new protein structure 3D viewer was integrated. The prediction of the intracellular localization of eukaryotic enzymes has been implemented. The new EnzymeDetector combines BRENDA enzyme annotations with protein and genome databases for the detection of eukaryotic and prokaryotic enzymes.

中文翻译：

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2021 年 ELIXIR 核心数据资源 BRENDA：新进展和更新

 抽象的

BRENDA酶数据库（https://www.brenda-enzymes.org）成立于1987年，现已发展成为功能性酶和代谢数据的主要集合。 2018年，BRENDA被选为ELIXIR核心数据资源。 BRENDA 提供可靠的数据、分类酶的持续管理和更新以及新发现的酶的整合。主要部分包含来自约 13 000 个生物体的约 90 000 种酶的超过 500 万个数据，这些数据是从约 157 000 篇原始文献参考文献中手动提取的，结合文本和数据挖掘、数据集成和预测算法的信息。补充内容包括疾病相关数据、蛋白质序列、3D 结构、基因组注释、配体信息、分类学、书目和动力学数据。 BRENDA 提供了对酶信息的轻松访问，从快速搜索到高级搜索、基于文本和结构化的酶-配体相互作用查询、字图和酶数据可视化。 BRENDA 路径图经过彻底修改和更新，以增强交互性和直观的可用性。酶摘要页面的新设计提供了对每种酶的改进访问。集成了新的蛋白质结构 3D 查看器。真核酶细胞内定位的预测已经实现。新的 EnzymeDetector 将 BRENDA 酶注释与蛋白质和基因组数据库相结合，用于检测真核和原核酶。