Abstract

NONCODE (http://www.noncode.org/) is a comprehensive database of collection and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals. NONCODEV6 is dedicated to providing the full scope of lncRNAs across plants and animals. The number of lncRNAs in NONCODEV6 has increased from 548 640 to 644 510 since the last update in 2017. The number of human lncRNAs has increased from 172 216 to 173 112. The number of mouse lncRNAs increased from 131 697 to 131 974. The number of plant lncRNAs is 94 697. The relationship between lncRNAs in human and cancer were updated with transcriptome sequencing profiles. Three important new features were also introduced in NONCODEV6: (i) updated human lncRNA-disease relationships, especially cancer; (ii) lncRNA annotations with tissue expression profiles and predicted function in five common plants; iii) lncRNAs conservation annotation at transcript level for 23 plant species. NONCODEV6 is accessible through http://www.noncode.org/.

中文翻译：

---

NONCODEV6：一个更新的数据库，专门用于动植物中较长的非编码RNA注释

摘要

NONCODE（http://www.noncode.org/）是收集和注释非编码RNA，尤其是动物中较长的非编码RNA（lncRNA）的综合数据库。NONCODEV6致力于提供跨动植物的lncRNA的完整范围。自2017年最后一次更新以来，NONCODEV6中的lncRNA数量已从548 640增加到644510。人类lncRNA的数量已从172 216增加到173112。小鼠lncRNA的数量从131 697增加到131 974。植物lncRNA的总数为94697。利用转录组测序概况更新了人与癌症中lncRNA的关系。NONCODEV6还引入了三个重要的新功能：（i）更新的人类lncRNA-疾病关系，尤其是癌症；（ii）五种常见植物中具有组织表达谱和预测功能的lncRNA注释；iii）在23种植物的转录本水平上对lncRNA的保守性注释。可通过http://www.noncode.org/访问NONCODEV6。