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In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2021-01-02 , DOI: 10.1002/jbio.202000322 Joanna Lazniewska 1 , Jack R T Darby 2 , Stacey L Holman 2 , Alexandra Sorvina 1 , Sally E Plush 3 , Massimiliano Massi 4 , Doug A Brooks 1 , Janna L Morrison 2
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2021-01-02 , DOI: 10.1002/jbio.202000322 Joanna Lazniewska 1 , Jack R T Darby 2 , Stacey L Holman 2 , Alexandra Sorvina 1 , Sally E Plush 3 , Massimiliano Massi 4 , Doug A Brooks 1 , Janna L Morrison 2
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Intrauterine growth restriction (IUGR) can result from reduced delivery of substrates, including oxygen and glucose, during pregnancy and may be caused by either placental insufficiency or maternal undernutrition. As a consequence of IUGR, there is altered programming of adipose tissue and this can be associated with metabolic diseases later in life. We have utilised two sheep models of IUGR, placental restriction and late gestation undernutrition, to determine the metabolic effects of growth restriction on foetal perirenal adipose tissue (PAT). Two‐photon microscopy was employed to obtain an optical redox ratio, which gives an indication of cell metabolism. PAT of IUGR foetuses exhibited higher metabolic activity, altered lipid droplet morphology, upregulation of cytochrome c oxidase subunit genes and decreased expression of genes involved in growth and differentiation. Our results indicate that there are adaptations in PAT of IUGR foetuses that might be protective and ensure survival in response to an IUGR insult.
中文翻译：
在子宫内底物受胎盘功能不全或母亲营养不良的限制，会降低胎儿肾周脂肪中的光学氧化还原比
宫内生长受限（IUGR）可能是由于怀孕期间底物（包括氧气和葡萄糖）的递送减少而引起的，并且可能是由于胎盘功能不全或孕产妇营养不良引起的。由于IUGR，脂肪组织的程序改变了，这可能与以后的代谢疾病有关。我们已经利用了IUGR的两个绵羊模型，胎盘限制和妊娠后期营养不良，来确定生长限制对胎儿肾周脂肪组织（PAT）的代谢作用。使用双光子显微镜获得光学氧化还原比，这表明细胞代谢。IUGR胎儿的PAT表现出更高的代谢活性，脂滴形态改变，上调细胞色素C氧化酶亚基基因的表达，减少与生长和分化有关的基因的表达。我们的结果表明，IUGR胎儿的PAT有适应性，可能具有保护性，并可确保对IUGR损伤的反应存活。
更新日期：2021-01-02
中文翻译：
在子宫内底物受胎盘功能不全或母亲营养不良的限制，会降低胎儿肾周脂肪中的光学氧化还原比
宫内生长受限（IUGR）可能是由于怀孕期间底物（包括氧气和葡萄糖）的递送减少而引起的，并且可能是由于胎盘功能不全或孕产妇营养不良引起的。由于IUGR，脂肪组织的程序改变了，这可能与以后的代谢疾病有关。我们已经利用了IUGR的两个绵羊模型，胎盘限制和妊娠后期营养不良，来确定生长限制对胎儿肾周脂肪组织（PAT）的代谢作用。使用双光子显微镜获得光学氧化还原比，这表明细胞代谢。IUGR胎儿的PAT表现出更高的代谢活性，脂滴形态改变，上调细胞色素C氧化酶亚基基因的表达，减少与生长和分化有关的基因的表达。我们的结果表明，IUGR胎儿的PAT有适应性，可能具有保护性，并可确保对IUGR损伤的反应存活。
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