Diurnal variation of corneal elasticity in healthy young human using air-puff optical coherence elastography,Journal of Biophotonics

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Diurnal variation of corneal elasticity in healthy young human using air-puff optical coherence elastography
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2021-01-02 , DOI: 10.1002/jbio.202000440
Sisi Chen ₁ , Zi Jin _{1,

2} , Gu Zheng ₁ , Shuling Ye ₁ , Yiyi Wang ₁ , Weicheng Wang ₁ , Yuanyuan Wang ₁ , Dexi Zhu ₁ , Meixiao Shen ₁ , Fan Lu ₁

Affiliation

Due to the disruption of intraocular pressure (IOP) and central corneal thickness (CCT), diurnal variation in normal young human corneal elasticity is not clear. Using the custom-built air-puff optical coherence elastography, one eye of 21 normal subjects is enrolled randomly to measure the central corneal elasticity, IOP, and CCT in different time points within a day. Based on the multi-level model, the corneal elastic modulus is found to have a linear positive relation with IOP (P < .01) but not CCT (P = .175) and time point (P = .174–.686). A new indicator, corneal elasticity change rate, is proposed to present the magnitude of corneal elasticity change caused by 1 mmHg IOP, which can correct the interference effect of IOP. The results show that the corneal elasticity in the normal young human does not have the characteristics of diurnal variation under IOP control. Furthermore, IOP plays an important role in the corneal elasticity, and corneal elasticity change rate can increase the comparability of results between individuals.

中文翻译：

使用吹气光学相干弹性成像技术研究健康年轻人角膜弹性的日变化

由于眼压（IOP）和中央角膜厚度（CCT）的破坏，正常年轻人角膜弹性的昼夜变化尚不清楚。使用定制的吹气光学相干弹性成像，随机招募21名正常人的一只眼睛，测量一天内不同时间点的中央角膜弹性、眼压和CCT。基于多级模型，发现角膜弹性模量与 IOP ( P < .01) 但与 CCT ( P = .175) 和时间点 ( P = .174–.686）。提出了一个新的指标角膜弹性变化率来呈现1 mmHg IOP引起的角膜弹性变化的大小，可以纠正IOP的干扰效应。结果表明，正常青年人的角膜弹性在眼压控制下不具有昼夜变化的特点。此外，眼压在角膜弹性中起着重要作用，角膜弹性变化率可以增加个体之间结果的可比性。

更新日期：2021-01-02

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