In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn( L ) 2 (TsO) 2 ]2DMF (1), {[Cd( L )(NO 3 ) 2 H 2 O)]DMF} n (2) (where L = 4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes ( 1 and 2 ) was confirmed by single-crystal X-ray analysis. Complex 1 has a discrete monomeric structure where L acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex 2 consists of polymeric {[Cd( L )(NO 3 ) 2 H 2 O)]DMF} n chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes ( 1 and 2 ) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use.

中文翻译：

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吡啶噻唑配体的两种金属络合物衍生物：合成、表征和生物活性

在这项工作中，两种新的金属 (II) 配合物与基于吡啶噻唑酮基团的配体，[Zn( L ) 2 (TsO) 2 ]2DMF (1), {[Cd( L )(NO 3 ) 2 H 2 O) ]DMF} n (2)（其中 L = 4-（吡啶-4-基）-2-（2-（吡啶-2-基亚甲基）肼基）噻唑），通过物理化学和光谱方法制备和表征。此外，通过单晶X射线分析证实了配合物（1和2）的结构。配合物 1 具有离散的单体结构，其中 L 作为通过吡啶氮和噻唑氮配位锌 (II) 原子的双齿试剂，而配合物 2 由聚合物 {[Cd( L )(NO 3 ) 2 H 2 O)] 组成DMF} n 链，其中镉 (II) 原子通过桥连配体连接。