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External validation of the ETV success score in 313 pediatric patients: a Brazilian single-center study
Neurosurgical Review ( IF 2.5 ) Pub Date : 2021-01-03 , DOI: 10.1007/s10143-020-01461-6
Leopoldo Mandic Ferreira Furtado 1 , José Aloysio da Costa Val Filho 1 , Eustaquio Claret Dos Santos Júnior 1
Affiliation  

The endoscopic third ventriculostomy (ETV) success score (ETVSS) was developed to predict the success rate of ETV at 6 months. In this study, the authors assessed the performance of this score for > 6 months, i.e., at 12 months, and provided external validation in Brazilian children. All children undergoing first ETV (without choroid plexus cauterization) at a Brazilian single institution for > 20 years were included in the study. The ETVSS was retrospectively calculated for each patient and compared with the actual success of the procedure observed at 6 and 12 months after the procedure. A total of 313 eligible children underwent initial ETV, 34.18% of whom had undergone shunt placement before ETV. The most common etiologies were aqueductal stenosis (45%) and non-tectal brain tumors (20.8%). ETV was successful at 6 months in 229 patients (73.16%) compared with the 61.3% predicted by the ETVSS. The overall actual success rate observed at 1 year after ETV was 65.1% (204 patients). The area under the receiver operating characteristic curve was 0.660 at 6 months and 0.668 at 1 year, which suggested a tendency for the ETVSS to underestimate the actual success rate of ETV at both timepoints. The ETVSS showed good success prediction in accordance with the actual ETV success rate and proved to be useful during the decision-making process of ETV.



中文翻译:

313 名儿科患者 ETV 成功评分的外部验证:巴西单中心研究

内窥镜第三脑室造口术 (ETV) 成功评分 (ETVSS) 旨在预测 6 个月时 ETV 的成功率。在这项研究中,作者评估了该评分在 6 个月以上(即 12 个月)的表现,并在巴西儿童中提供了外部验证。所有在巴西单一机构接受首次 ETV(无脉络丛烧灼术)> 20 年的儿童均被纳入该研究。ETVSS 对每位患者进行回顾性计算,并与手术后 6 个月和 12 个月观察到的手术实际成功情况进行比较。共有 313 名符合条件的儿童接受了初始 ETV,其中 34.18% 在 ETV 之前接受了分流安置。最常见的病因是导水管狭窄 (45%) 和非顶盖脑肿瘤 (20.8%)。ETV 在 6 个月时在 229 名患者 (73.16%) 中成功,而 ETVSS 预测的成功率为 61.3%。ETV 后 1 年观察到的总体实际成功率为 65.1%(204 名患者)。接受者操作特征曲线下面积在 6 个月时为 0.660,在 1 年时为 0.668,这表明 ETVSS 有低估 ETV 在两个时间点的实际成功率的趋势。ETVSS 根据实际 ETV 成功率显示出良好的成功预测,并在 ETV 的决策过程中证明是有用的。这表明 ETVSS 倾向于低估 ETV 在两个时间点的实际成功率。ETVSS 根据实际 ETV 成功率显示出良好的成功预测,并在 ETV 的决策过程中证明是有用的。这表明 ETVSS 倾向于低估 ETV 在两个时间点的实际成功率。ETVSS 根据实际 ETV 成功率显示出良好的成功预测,并在 ETV 的决策过程中证明是有用的。

更新日期:2021-01-03
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