Information about Parkinson’s disease (PD) patients with severe COVID-19 is scarce. We aimed to analyze the clinical characteristics, outcomes, and risk factors affecting the prognosis of PD patients with severe COVID-19 infection. Clinical data of severe COVID-19 patients admitted at the Union Hospital, Wuhan between 28th January and 29th February 2020 were collected and analyzed. 10 patients (1.96%) had a medical history of PD with a mean (SD) age of 72.10 (± 11.46) years. The clinical characteristics and outcomes of severe COVID-19 with and without PD patients were then compared. There was no significant difference in overall mortality between the PD and non-PD patients with severe COVID-19 (p > 0.05). In PD patients with severe COVID-19, the proportion of patients with critical type, disturbance of consciousness, incidence of complications, white blood cells count and neutrophils counts on admission seem higher in the non-survivors. PD patients with older age, longer PD duration, and late stage PD may be highly susceptible to critical COVID-19 infection and bad outcome. The PD patients with consciousness disorders and complications that progressed rapidly are at increased risk of death.

有关患有重症 COVID-19 的帕金森病 (PD) 患者的信息很少。我们的目的是分析重症 COVID-19 感染 PD 患者的临床特征、结局和影响预后的危险因素。收集并分析2020年1月28日至2月29日期间武汉协和医院收治的重症COVID-19患者的临床数据。 10 名患者 (1.96%) 有 PD 病史，平均 (SD) 年龄为 72.10 (± 11.46) 岁。然后比较患有和不患有帕金森病的重症 COVID-19 患者的临床特征和结果。患有严重 COVID-19 的 PD 和非 PD 患者的总体死亡率没有显着差异 ( p > 0.05)。在重症COVID-19 PD患者中，非幸存者中重症、意识障碍、并发症发生率、入院时白细胞计数和中性粒细胞计数的患者比例似乎更高。年龄较大、PD持续时间较长、处于晚期的PD患者可能极易受到严重的COVID-19感染并导致不良预后。意识障碍和并发症迅速进展的PD患者死亡风险增加。