Heterocyclic compounds occur widely in nature and in drug molecules. The activity of many nitrogen-containing heterocyclic compounds is unique. For example, 1,4-dihydropyridines display good antitumor and antibacterial effects and can be commercially used as calcium channel blocker agents in the treatment of cardiovascular diseases. To reduce the use of toxic catalysts in the synthesis of 1,4-dihydropyridines, here we designed cobalt carbon nanotubes as a heterogeneous catalyst. We report the efficient synthesis of 1,4-dihydropyridines under mild conditions, which allows to access a wide array of 1,4-dihydropyridines from aromatic aldehyde in high yields, up to 96%. Advantages include the use of ethanol as solvent, low catalyst loading of 6% mol, short reaction time of 5–15 min, easy preparation and recyclable catalyst.

杂环化合物广泛存在于自然界和药物分子中。许多含氮杂环化合物的活性是独特的。例如，1，4-二氢吡啶类显示出良好的抗肿瘤和抗菌作用，并且可以在商业上用作治疗心血管疾病的钙通道阻滞剂。为了减少有毒催化剂在1,4-二氢吡啶的合成中的使用，我们在此设计了钴碳纳米管作为非均相催化剂。我们报告了在温和的条件下有效合成1,4-二氢吡啶，它可以从芳族醛中以高达96％的高收率获得各种各样的1,4-二氢吡啶。优势包括使用乙醇作为溶剂，催化剂负载量低至6％mol，反应时间短（5–15分钟），易于制备和可回收的催化剂。