Purpose

To quantify metamorphopsia with a novel objective method in patients with epiretinal membrane (ERM) and to compare the relationships among metamorphopsia scores, spectral-domain optical coherence tomography (OCT) findings, and multifocal electroretinogram (mfERG) results.

Methods

This study included 52 eyes of 52 patients with idiopathic ERM who underwent comprehensive ophthalmologic examinations, including measurement of best-corrected visual acuity (BCVA), OCT, and mfERG. The degree of metamorphopsia was quantified using MonPack One® (Metrovision, Perenchies, France). On the topographic map of the early treatment diabetic retinopathy (ETDRS) grid, retinal thickness in the central, superior, inferior, nasal, and temporal subfields were measured, and metamorphopsia scores for each corresponding subfield were also obtained. The amplitudes and implicit times of mERG were elicited from each subfield. Then, the correlations among metamorphopsia scores, OCT findings, and mfERG responses were analyzed.

Results

The mean age of the patients was 65.3 ± 18.5 y, and the average metamorphopsia score of the individual subfields was 2.03 ± 1.18. Initial BCVA was 0.50 ± 0.12 logMAR, but there was no significant correlation between metamorphopsia scores and BCVA. The metamorphopsia scores from the central subfields showed significant correlations with central retinal thickness (CRT) (p = 0.001). The mean metamorphopsia scores in the central subfield showed a significant relationship with the mean N1 and P1 amplitudes (p = 0.001, p = 0.048, respectively), while no relationship was observed between metamorphopsia scores and mfERG amplitudes in other subfields.

Conclusions

The degree of metamorphopsia in patients with ERM could be objectively quantified in each subfield using a novel metamorphopsia test. The metamorphopsia scores were significantly correlated with retinal thickness, especially at the central subfields, and the scores in the central subfields were significantly correlated with the N1 and P1 amplitudes of mfERG. Thus, the metamorphopsia test can be a useful method to evaluate metamorphopsia symptoms for patients with ERM.

中文翻译：

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视网膜前膜患者变形视检查分数、光学相干断层扫描结果和多焦视网膜电图反应之间的相关性

目的

用一种新的客观方法量化视网膜前膜 (ERM) 患者的变形，并比较变形评分、光谱域光学相干断层扫描 (OCT) 发现和多焦视网膜电图 (mfERG) 结果之间的关系。

方法

这项研究包括 52 名特发性 ERM 患者的 52 只眼，他们接受了全面的眼科检查，包括最佳矫正视力 (BCVA)、OCT 和 mfERG 的测量。变形视的程度使用 MonPack One® (Metrovision, Perenchies, France) 进行量化。在早期治疗糖尿病视网膜病变 (ETDRS) 网格的地形图上，测量了中央、上、下、鼻和颞亚区的视网膜厚度，并获得了每个相应亚区的变形评分。mERG 的幅度和隐含时间是从每个子场中引出的。然后，分析变形视评分、OCT 结果和 mfERG 反应之间的相关性。

结果

患者的平均年龄为 65.3 ± 18.5 岁，各个亚视野的平均变形评分为 2.03 ± 1.18。初始 BCVA 为 0.50 ± 0.12 logMAR，但变形视评分与 BCVA 之间没有显着相关性。中央亚视场的变形评分显示出与中央视网膜厚度 (CRT) 的显着相关性 ( p  = 0.001)。中央亚视场的平均变形评分与平均 N1 和 P1 振幅显着相关（分别为p  = 0.001、p  = 0.048），而在其他亚视场中未观察到变形视评分与 mfERG 振幅之间的关系。

结论

ERM 患者的变形程度可以使用新的变形测试在每个子域中客观量化。视物变形评分与视网膜厚度显着相关，尤其是在中央亚视野，中央亚视野的评分与 mfERG 的 N1 和 P1 幅度显着相关。因此，变形视检测可以成为评估 ERM 患者变形视症状的有用方法。