The AAA-ATPase p97/Cdc48 is one of the most abundant proteins in eukaryotes, and owing to its multiple functions, is considered the swiss army knife of cells. Recent findings demonstrate that p97/Cdc48 and its cofactor p47/Shp1 control the heavy metal stress response by active, signal-triggered disassembly of a multisubunit ubiquitin ligase. Here we review this pathway and describe recently achieved mechanistic insight into the role of p47/Shp1 in this process.

中文翻译：

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Cdc48/Shp1 参与蛋白质复合物的解离以调节其活性

AAA-ATPase p97/Cdc48 是真核生物中最丰富的蛋白质之一，由于其多种功能，被认为是细胞的瑞士军刀。最近的研究结果表明，p97/Cdc48 及其辅因子 p47/Shp1 通过多亚基泛素连接酶的主动、信号触发分解来控制重金属应激反应。在这里，我们回顾了这条途径，并描述了最近对 p47/Shp1 在这个过程中的作用的机制洞察。