Bone is not only a mineralized and apparently non-vital structure that provides support for locomotion and protection to inner organs. An increasing number of studies are unveiling new biologic functions and connections to other systems, giving the rise to new fields of research, such as osteoimmunology. The bone marrow niche, a new entity in bone physiology, seems to represent the site where a complex crosstalk between bone and immune/inflammatory responses takes place. An impressive interplay with the immune system is realized in bone marrow, with reciprocal influences between bone cells and haematopoietic cells. In this way, systemic chronic inflammatory diseases realize a crosstalk with bone, resulting in bone disease. Thus, pathogenetic links between chronic kidney disease-mineral bone disorders and osteoporosis, cardiovascular disease, and ageing are common. The aim of this narrative review is to provide a general view of the progresses in the field of bone research and their potential clinical implications, with emphasis on the links with inflammation and the connections to osteoimmunology and chemokines.

骨骼不仅是一种矿化且明显无生命的结构，可为运动提供支持并保护内部器官。越来越多的研究揭示了新的生物学功能以及与其他系统的联系，从而催生了新的研究领域，例如骨免疫学。骨髓生态位是骨骼生理学中的一个新实体，似乎代表了骨骼和免疫/炎症反应之间发生复杂串扰的部位。在骨髓中实现了与免疫系统的令人印象深刻的相互作用，骨细胞和造血细胞之间存在相互影响。这样，全身性慢性炎症性疾病就实现了与骨的串扰，从而导致骨病。因此，慢性肾病-矿物质骨疾病与骨质疏松症、心血管疾病、和老化很常见。这篇叙述性综述的目的是对骨骼研究领域的进展及其潜在的临床意义提供一个总体看法，重点是与炎症的联系以及与骨免疫学和趋化因子的联系。