Accumulating evidence shows that histologic transformation is involved in the drug resistance of lung cancer. Moreover, it is common for lung adenocarcinoma to transform into small-cell lung cancer or squamous cell carcinoma; however, clinical cases with sarcomatoid transformation have been rarely reported. Thus, both the diagnosis and treatment of lung adenocarcinoma with sarcomatoid transformation remain difficult. Here, we discuss two patients with lung adenocarcinoma with sarcomatoid transformation—analyzing the diagnosis, clinical features, immunohistochemical characteristics, therapy, and prognosis—with the hope that this report will be used as a reference for future treatment of these patients.

中文翻译：

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2例肺腺癌治疗后转化为肺肉瘤样癌

越来越多的证据表明，组织学转化与肺癌的耐药性有关。此外，肺腺癌常转变为小细胞肺癌或鳞状细胞癌；然而，很少报道肉瘤样转化的临床病例。因此，伴有肉瘤样转化的肺腺癌的诊断和治疗仍然很困难。在这里，我们讨论了两名伴有肉瘤样转化的肺腺癌患者——分析诊断、临床特征、免疫组织化学特征、治疗和预后——希望本报告能够作为这些患者未来治疗的参考。