Effects of oral sialic acid on gut development, liver function, and gut microbiota in mice,Letters in Applied Microbiology

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Effects of oral sialic acid on gut development, liver function, and gut microbiota in mice
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2021-01-01 , DOI: 10.1111/lam.13447
J Ma ₁ , S Gong ₁ , Y He ₁ , W Gao ₂ , W Hao ₁ , X Lan ₁

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Sialic acid (N-acetylneuraminic acid), a 9-carbon monosaccharide, has been widely studied in immunology, oncology, and neurology. However, the effects of sialic acid on organ and intestinal development, liver function and gut microbiota were rarely studied. In this study, we found that oral sialic acid tended to increase the relative weight of liver and decreased the serum aspartate aminotransferase (GPT) activity. In addition, sialic acid treatment markedly reduced gut villus length, depth, the ratio of villus length/depth (L/D), areas, width, and the number of goblet cells. Furthermore, gut microbes were changed in response to oral oral sialic acid, such as Staphylococcus lentus, Corynebacterium stationis, Corynebacterium urealyticum, Jeotgalibaca sp_PTS2502, Ignatzschineria indica, Sporosarcina pasteurii, Sporosarcina sp_HW10C2, Facklamia tabacinasalis, Oblitimonas alkaliphila, Erysipelatoclostridium ramosum, Blautia sp_YL58, Bacteroids thetaiotaomicron, Morganella morganii, Clostridioides difficile, Helicobacter tryphlonius, Clostridium sp_Clone47, Alistipes finegoldii, [pseudomonas]_geniculata and Pseudomonas parafulva at the species level. In conclusion, oral sialic acid altered the intestinal pathological state and microbial compositions, and the effect of sialic acid on host health should be further studied.

中文翻译：

口服唾液酸对小鼠肠道发育、肝功能和肠道菌群的影响

唾液酸（N-乙酰神经氨酸）是一种 9 碳单糖，已在免疫学、肿瘤学和神经病学中得到广泛研究。然而，很少研究唾液酸对器官和肠道发育、肝功能和肠道微生物群的影响。在这项研究中，我们发现口服唾液酸倾向于增加肝脏的相对重量并降低血清天冬氨酸转氨酶（GPT）活性。此外，唾液酸处理显着降低了肠绒毛长度、深度、绒毛长度/深度比 (L/D)、面积、宽度和杯状细胞的数量。此外，肠道微生物因口服唾液酸而发生变化，例如迟缓葡萄球菌、静止棒状杆菌、解脲棒杆菌、Jeotgalibaca sp_PTS2502、Ignatzschineria indica、Sporosarcina pasteurii、Sporosarcina sp_HW10C2、Facklamia tabacinasalis、Oblitimonasalkaliphila、Erysipelatoclostridium ramosum、Blautia sp_YL58、Bacteroids thetaiotaomicron、Morganella morganii、Clostridioides difficile、Helicobacter tryphlonius、Clostridium sp_Clone47、Paratus 总之，口服唾液酸改变了肠道病理状态和微生物组成，唾液酸对宿主健康的影响应进一步研究。

更新日期：2021-01-01

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