Identification of prognostic factors for perivascular wall tumours (PWTs) is desirable to accurately predict prognosis and guide treatment. 100 and two dogs with surgically excised PWTs without distant metastasis were retrospectively enrolled in this multi‐institutional study, and the impact of pre‐treatment leukocyte parameters, clinical and histopathological variables on local recurrence (LR) and overall‐survival time (OST) were evaluated. Increasing values of white blood cell count (WBCC), neutrophil count (NC) and neutrophil‐to‐lymphocyte ratio (NLR) were significantly correlated with the hazard of LR in univariate analysis. WBCC and NC remained prognostic when adjusted for margins, grade, tumour size, location and skin ulceration, but lost their significance when adjusted for mitotic index and necrosis, whilst NLR remained prognostic only when close margins where categorised as infiltrated. Castrated males had a higher hazard of LR than intact males in univariate analysis, but significance was lost in multivariate models. Ulcerated PWTs and those located on the distal extremities had a higher hazard of LR both in univariate and multivariate analysis. Histological grade, necrosis, mitotic count, and infiltrated margins were all associated with LR both in univariate and multivariate analysis. Boxer breed, older age, ulceration, grade III, necrosis >50% and higher mitotic count were correlated with shorter OST, although breed and age lost their significance in multivariate analysis. Prognostication of surgically excised PWTs should be based on both clinical and histopathological variables. If validated in further studies, leukocyte counts and NLR may aid the clinician in identifying dogs at higher risk of LR before treatment.

中文翻译：

---

临床、血液学和组织病理学变量对 102 例犬皮肤血管周围壁肿瘤的预后影响

确定血管周围壁肿瘤（PWTs）的预后因素对于准确预测预后和指导治疗是十分必要的。这项多机构研究回顾性纳入了 100 只手术切除的 PWT 和两只没有远处转移的狗，治疗前白细胞参数、临床和组织病理学变量对局部复发 (LR) 和总生存时间 (OST) 的影响是评估。在单变量分析中，白细胞计数（WBCC）、中性粒细胞计数（NC）和中性粒细胞与淋巴细胞比率（NLR）的增加值与 LR 的危害显着相关。WBCC 和 NC 在调整边缘、分级、肿瘤大小、位置和皮肤溃疡后仍然具有预后意义，但在调整有丝分裂指数和坏死时失去了意义，而 NLR 只有在接近边缘被归类为渗透时才保持预后。在单变量分析中，阉割男性的 LR 风险高于完整男性，但在多变量模型中失去了显着性。在单变量和多变量分析中，溃疡性 PWT 和位于四肢远端的 PWT 具有更高的 LR 风险。在单变量和多变量分析中，组织学分级、坏死、有丝分裂计数和浸润边缘均与 LR 相关。拳击手品种、年龄较大、溃​​疡、III 级、坏死 >50% 和较高的有丝分裂计数与较短的 OST 相关，尽管品种和年龄在多变量分析中失去了意义。手术切除 PWT 的预后应基于临床和组织病理学变量。如果在进一步的研究中得到验证，