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The dilemma of herd immunity for COVID‐19
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2021-01-02 , DOI: 10.1002/jmv.26768
Seyed Aria Nejadghaderi 1, 2 , Saeid Safiri 3, 4
Affiliation  

In late December 2019, a novel species of the coronavirus family, which was further called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) or 2019‐novel coronavirus, caused pneumonia‐like presentations in a cluster of people in Wuhan, China.1 Following the SARS and Middle East respiratory syndrome pandemics in 2002–2004 and 2012–2014, respectively, the coroanvirus disease 2019 (COVID‐19) pandemic is the third in the current century.2 Since its identification, there have been a number of hypotheses about its etiology.3 Bats4 and being man‐made5 are two examples, with the latter having been discredited by multiple experts. The COVID‐19 presentations have a wide range and affect several systems, including the: respiratory system (pneumonia, sore throat, rhinorrhea, hemoptysis, and sneezing), gastrointestinal system (diarrhea and vomiting), cardiac system (acute cardiac injury), nervous system (axial hypotonia, drowsiness, headache, and moaning sounds), as well as systemic clinical presentations (fatigue, fever, hypoxemia, and lymphopnea).6, 7 Considering the fact that SARS‐CoV‐2 is transmitted through droplets, contaminated surfaces, and less likely through aerosols and vertical transmission,8 prevention, and control guidelines have been developing to reduce its prevalence, mostly by reducing human face‐to‐face contact.

To our knowledge, the term “herd immunity” came from a paper published in 1923.9 The goal of herd immunity is to protect a group of people from becoming affecting by diseases, especially infectious diseases, through the immunization of a large proportion of the population.10 Herd immunity can be achieved in a variety of ways, with vaccination coverage being the most well‐known method.11 The required thresholds needed for herd immunity to eradicate or control different diseases are not the same.12 The estimated percent of the population that need to be immune to SARS‐CoV‐2, to reach herd immunity, range from 50% to 85% in countries with a high prevalence.13 At the time of writing, there have been no approved vaccinations for COVID‐19,14 meaning that the only currently available method for developing herd immunity is via the natural infection of a specific threshold of each community.

One of the approaches to control pandemics is through the development of herd immunity.15 Approaching the COVID‐19 pandemic through the development of herd immunity has the following pros and cons:

更新日期:2021-01-02
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