Rehabilitative exercise outcomes and plasma concentrations of soluble adhesion molecules (sEndoglin, sE-Selectin, sL-Selectin, sICAM-1, sNCAM, sNCAM-1, sVCAM-1, sPECAM-1, sVAP-1) were evaluated in 60 severely disabled progressive multiple sclerosis (MS) patients at 4-time points. Changes of sE-Selectin, sL-Selectin, and sPECAM-1 concentrations were observed over time, and their variations were significantly correlated with rehabilitative outcome variations. Baseline sVAP-1 concentrations were able to predict functional mobility recovery. Our data suggest that the evaluation of adhesion molecules in plasma provides useful information to interpret rehabilitative exercise processes and to identify potential predictors of the rehabilitation-induced changes in mobility outcomes in MS patients.

中文翻译：

---

可溶性粘附分子血浆浓度的基线和随时间变化与多发性硬化患者康复后的活动能力恢复有关

在 60 名严重残疾的渐进性患者中评估了康复运动结果和可溶性粘附分子（sEndoglin、sE-Selectin、sL-Selectin、sICAM-1、sNCAM、sNCAM-1、sVCAM-1、sPECAM-1、sVAP-1）的血浆浓度4 个时间点的多发性硬化 (MS) 患者。随着时间的推移观察到 sE-Selectin、sL-Selectin 和 sPECAM-1 浓度的变化，并且它们的变化与康复结果的变化显着相关。基线 sVAP-1 浓度能够预测功能活动性恢复。我们的数据表明，血浆中粘附分子的评估提供了有用的信息来解释康复运动过程，并确定康复引起的 MS 患者活动结果变化的潜在预测因素。