Abstract

Novel derivatives of 2-(2,2′-diamino-4,5′-bipyrimidin-6-yl)phenols(naphthols) were obtained in the reaction of (4-amino-2H-(benzo[g])chromen-2-ylidene)malondialdehyde with 1,3-dinucleophile proceeding as a cascade reaction initiated by the Michael reaction. It has been established that the recyclization of 2-aryl-4H-chromen-4-imines under the influence of malononitrile as C-nucleophile is completed by the formation of 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitrile by the 6-exo-trig-cyclization mechanism.

Graphic abstract

中文翻译：

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合成未知的2-（2,2'-二氨基-4,5'-双嘧啶-6-基）酚（萘酚）和2-氨基-6-（2-羟基苯基）-4-（4-硝基苯基）烟腈

摘要

在（4-氨基-2 H-（苯并[ g ]）铬烯-的反应中获得了2-（2,2'-二氨基-4,5'-联嘧啶-6-基）酚（萘酚）的新型衍生物2-亚丙基）丙二醛与1，3-二亲核试剂的反应是由迈克尔反应引发的级联反应。已经确定，通过形成2-氨基-6-（2-羟基苯基）-4-（），在丙二腈作为C-亲核试剂的影响下，2-芳基-4 H-铬--4-亚胺的再循环得以完成。 4-硝基苯基）烟腈通过6-exo-trig-环化机理生成。

图形摘要