The T2 Candida Panel (T2CP) has high sensitivity and specificity to detect candidemia. Its role in the diagnosis and management of candidemia compared to blood cultures (BC) remains unclear. The purpose of this study was to evaluate the T2CP versus BC in detecting and treating candidemia. A retrospective, observational cohort study was conducted to compare clinical outcomes in patients with candidemia identified by BC versus T2CP. Patients with a positive BC or T2CP for Candida spp. from January 2012 to August 2020 were grouped by initial method of detection (BC vs T2CP). Co-primary endpoints assessed included time to detection of candidemia and time to antifungal therapy. Key secondary endpoints included length of stay (LOS), ICU LOS, and mortality. One hundred sixty-three patients with a positive BC and 89 patients with a positive T2CP were included in the evaluation. The average time to detection of candidemia was significantly shorter in the T2CP group compared to BC group (9 vs 41 h, p < 0.001). The time to antifungal was also significantly shorter in the T2CP group compared to the BC group (4 vs 37 h, p < 0.001). However, LOS was significantly shorter in the BC positive group than the T2CP group with no difference in ICU LOS. There was no difference in in-hospital or 30-day mortality between the two groups. Of patients diagnosed with candidemia at our large community hospital, identification by T2CP led to faster detection and initiation of antifungal compared to blood cultures without improvement in LOS or mortality.

T2 念珠菌检测组 (T2CP) 具有检测念珠菌血症的高灵敏度和特异性。与血培养 (BC) 相比，其在诊断和管理念珠菌血症中的作用仍不清楚。本研究的目的是评估 T2CP 与 BC 在检测和治疗念珠菌血症方面的比较。进行了一项回顾性、观察性队列研究，以比较 BC 与 T2CP 确定的念珠菌血症患者的临床结果。念珠菌BC 或 T2CP 阳性的患者属 2012 年 1 月至 2020 年 8 月按初始检测方法分组（BC vs T2CP）。评估的共同主要终点包括检测念珠菌血症的时间和抗真菌治疗的时间。关键次要终点包括住院时间 (LOS)、ICU LOS 和死亡率。163 名 BC 阳性患者和 89 名 T2CP 阳性患者被纳入评估。与 BC 组相比，T2CP 组检测念珠菌血症的平均时间显着缩短（9 小时 vs 41 小时，p  < 0.001）。与 BC 组相比，T2CP 组的抗真菌时间也显着缩短（4 小时 vs 37 小时，p < 0.001)。然而，BC 阳性组的 LOS 显着短于 T2CP 组，ICU LOS 没有差异。两组之间的住院死亡率或 30 天死亡率没有差异。在我们的大型社区医院诊断为念珠菌血症的患者中，与血培养相比，通过 T2CP 进行识别可以更快地检测和启动抗真菌药，而没有改善 LOS 或死亡率。