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Reference man for radiological protection: 71 chemical elements’ content of the prostate gland (normal and cancerous)
Radiation and Environmental Biophysics ( IF 1.5 ) Pub Date : 2021-01-02 , DOI: 10.1007/s00411-020-00884-5
Vladimir Zaichick 1 , Sinclair Wynchank 2
Affiliation  

Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues of the Reference (European Caucasian) Man are suggested as a result of this work. Autopsies of 37 apparently healthy males (mean age 55 ± 11 years, range 41–87 years) provided the prostatic tissues studied. The investigated individuals lived in a non-industrial, Central European region of Russia and had suffered sudden death. Also, tissues were studied from 62 subjects with prostate cancer (mean age 65 ± 10 years, range 40–79 years). Sixty-seven elemental mass fractions were determined in each of these 99 prostates. Analytical methods employed were inductively coupled plasma atomic emission spectrometry, neutron activation analysis with high-resolution spectrometry of short-lived and long-lived radionuclides, energy dispersive X-ray fluorescence analysis, and inductively coupled plasma mass spectrometry. Whichever method was employed, the necessary quality control measures were utilized. Results presented here include a systematic analysis of both the prostatic data presented here for 67 elements and also others’ published findings, to make a total of 71 elemental mass fraction values.



中文翻译:

放射防护参考人:前列腺中71种化学元素的含量(正常和癌变)

对于多种应用,通常需要人体器官和组织的元素含量方面的知识。这些措施包括近距离放射治疗和放射治疗计划,辐射剂量测定和辐射防护。由于这项工作,建议对参考人(欧洲高加索人)的正常和癌性前列腺组织中化学元素质量分数的参考值进行修订。对37名表面健康的男性进行尸检(平均年龄55±11岁,范围41-87岁),提供了所研究的前列腺组织。被调查者居住在俄罗斯非工业化的中欧地区,并猝死。此外,还从62位前列腺癌患者(平均年龄65±10岁,范围40-79岁)中研究了组织。在这99个前列腺中的每个前列腺中确定了67个元素质量分数。所使用的分析方法是电感耦合等离子体原子发射光谱法,中子活化分析和短寿命和长寿命放射性核素的高分辨率光谱法,能量色散X射线荧光分析以及电感耦合等离子体质谱法。无论采用哪种方法,都必须使用必要的质量控制措施。此处提供的结果包括对此处提供的有关67种元素的前列腺数据以及其他人的已发表发现的系统分析,从而得出总计71种元素质量分数值。无论采用哪种方法,都必须使用必要的质量控制措施。此处提供的结果包括对此处提供的有关67种元素的前列腺数据以及其他人的已发表发现的系统分析,从而得出总计71种元素质量分数值。无论采用哪种方法,都必须使用必要的质量控制措施。此处提供的结果包括对此处提供的有关67种元素的前列腺数据以及其他人的已发表发现的系统分析,从而得出总计71种元素质量分数值。

更新日期:2021-01-02
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